Autoradiographic localization of3H-ORG 2058, a synthetic progestin, in the mammary glands of the baboon

Frank J. Weaker, Peter J. Sheridan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The uptake and retention of a radiolabeled synthetic progestin ORG 2058 by the mammary glands were examined in the baboon. Four estrogen-primed baboons were injected intravenously with 2.5 μg/kg body weight of3H-ORG 2058. One animal received an additional injection of 2.5 mg/kg body weight of unlabeled progesterone. One hour after the injections, the animals were killed and the mammary glands were removed and processed for autoradiography. Only 13.4% of the alveolar secretory cells studied demonstrated nuclear uptake and retention of the radiolabeled steroid, while 60% of the alveoli demonstrated at least 1 labeled cell per cross-section. The fibroblasts in the interlobular connective tissue and most of the cells lining the interlobular ducts were labeled; however, no cells in the intralobular connective tissue were labeled. These observations seem to indicate that all alveolar secretory cells do not contain progesterone receptors in the normal mammary gland.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalBreast Cancer Research and Treatment
Issue number2
StatePublished - Jun 1984


  • autoradiography
  • baboon
  • mammary glands
  • progesterone

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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