Autoradiographic evidence of sex steroid receptors in laryngeal tissues of the baboon (Papio cynocephalus)

Thomas B. Aufdemorte, Peter J. Sheridan, G. Richard Holt

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

A number of studies have implicated the gonadal steroids as significant factors in laryngeal development and disease. In addition, antiandrogens are receiving limited trials in the treatment of laryngeal carcinoma. However, there is little experimental data to document the presence, and more specifically the location of receptors for the sex steroid hormones in the larynx. The purpose of this study is to provide such data. Utilizing an autoradiographic technique, tissues from baboons injected with tritiated estradiol (JH-E2) or dihy-drotestosterone testosterone ('H-DHT) were examined and analyzed. The data gathered confirmed that the larynx is rich in receptors for these steroids and that there are specific patterns of distribution of receptor positive cells. The vocalis muscle and other mesenchymal tissues contained the largest number of receptors, while ciliated columnar and stratified squamous epithelium were negative. The significance of these findings is discussed.

Original languageEnglish (US)
Pages (from-to)1607-1611
Number of pages5
JournalLaryngoscope
Volume93
Issue number12
DOIs
StatePublished - Dec 1983

ASJC Scopus subject areas

  • Otorhinolaryngology

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