Automated Talairach Atlas labels for functional brain mapping

Jack L Lancaster, Marty G. Woldorff, Lawrence M. Parsons, Mario Liotti, Catarina S. Freitas, Lacy Rainey, Peter V. Kochunov, Dan Nickerson, Shawn A. Mikiten, Peter T Fox

Research output: Contribution to journalArticle

2452 Citations (Scopus)

Abstract

An automated coordinate-based system to retrieve brain labels from the 1988 Talairach Atlas, called the Talairach Daemon (TD), was previously introduced [Lancaster et al., 1997]. In the present study, the TD system and its 3-D database of labels for the 1988 Talairach atlas were tested for labeling of functional activation foci. TD system labels were compared with author-designated labels of activation coordinates from over 250 published functional brain-mapping studies and with manual atlas-derived labels from an expert group using a subset of these activation coordinates. Automated labeling by the TD system compared well with authors' labels, with a 70% or greater label match averaged over all locations. Author-label matching improved to greater than 90% within a search range of ±5 mm for most sites. An adaptive grey matter (GM) range-search utility was evaluated using individual activations from the M1 mouth region (30 subjects, 52 sites). It provided an 87% label match to Brodmann area labels (BA 4 and BA 6) within a search range of ±5 mm. Using the adaptive GM range search, the TD system's overall match with authors' labels (90%) was better than that of the expert group (80%). When used in concert with authors' deeper knowledge of an experiment, the TD system provides consistent and comprehensive labels for brain activation foci. Additional suggested applications of the TD system include interactive labeling, anatomical grouping of activation foci, lesion- deficit analysis, and neuroanatomy education. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)120-131
Number of pages12
JournalHuman Brain Mapping
Volume10
Issue number3
DOIs
StatePublished - Jul 2000

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Brain Mapping
Atlases
Neuroanatomy
Brain
Mouth
Databases
Education
Gray Matter

Keywords

  • Brain labels
  • Talairach Daemon
  • Talairach Labels
  • Volume occupancy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

Lancaster, J. L., Woldorff, M. G., Parsons, L. M., Liotti, M., Freitas, C. S., Rainey, L., ... Fox, P. T. (2000). Automated Talairach Atlas labels for functional brain mapping. Human Brain Mapping, 10(3), 120-131. https://doi.org/10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8

Automated Talairach Atlas labels for functional brain mapping. / Lancaster, Jack L; Woldorff, Marty G.; Parsons, Lawrence M.; Liotti, Mario; Freitas, Catarina S.; Rainey, Lacy; Kochunov, Peter V.; Nickerson, Dan; Mikiten, Shawn A.; Fox, Peter T.

In: Human Brain Mapping, Vol. 10, No. 3, 07.2000, p. 120-131.

Research output: Contribution to journalArticle

Lancaster, JL, Woldorff, MG, Parsons, LM, Liotti, M, Freitas, CS, Rainey, L, Kochunov, PV, Nickerson, D, Mikiten, SA & Fox, PT 2000, 'Automated Talairach Atlas labels for functional brain mapping', Human Brain Mapping, vol. 10, no. 3, pp. 120-131. https://doi.org/10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8
Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L et al. Automated Talairach Atlas labels for functional brain mapping. Human Brain Mapping. 2000 Jul;10(3):120-131. https://doi.org/10.1002/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8
Lancaster, Jack L ; Woldorff, Marty G. ; Parsons, Lawrence M. ; Liotti, Mario ; Freitas, Catarina S. ; Rainey, Lacy ; Kochunov, Peter V. ; Nickerson, Dan ; Mikiten, Shawn A. ; Fox, Peter T. / Automated Talairach Atlas labels for functional brain mapping. In: Human Brain Mapping. 2000 ; Vol. 10, No. 3. pp. 120-131.
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