Autoimmune thyroid diseases in children

Prasanthi Pasala, Gary L. Francis

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Introduction: Autoimmune thyroid diseases (AIT) are common in children and may present with a variety of signs and symptoms including: euthyroid goiter, hypothyroidism, or hyperthyroidism. The natural history of AIT may be different in children but in all age groups, there appear to be genetic risk factors and environmental triggers that initiate thyroid autoimmunity. Areas covered: In this review, we summarize recent studies that investigate the genetics and environmental triggers believed to be involved in thyroid autoimmunity. We also discuss the approach and controversies in the treatment of children with AIT. Expert commentary: Much has been learned about the major roles for genetics, cytokines, regulatory lymphocytes, and environmental triggers in CLT but controversies remain.

Original languageEnglish (US)
Pages (from-to)129-142
Number of pages14
JournalExpert Review of Endocrinology and Metabolism
Volume12
Issue number2
DOIs
StatePublished - Mar 4 2017
Externally publishedYes

Keywords

  • autoimmune
  • children
  • goiter
  • Graves’ disease
  • Hashimoto thyroiditis
  • Thyroid

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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