Autoantibodies to p53 in sera of patients with autoimmune thyroid disease

Cydney L. Fenton, Aneeta Patel, R. Michael Tuttle, Gary L. Francis

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Mutations in the tumor suppressor gene, p53, lead to intracellular accumulation of abnormal p53 protein and are associated with p53 autoantibodies, p53 also accumulates in autoimmune diseases and Hashimoto's thyroiditis, but it is unknown if p53 autoantibodies occur in the latter. We measured p53 autoantibodies in the sera of 93 patients with thyroid disease and 19 patients without thyroid disease. Anti-p53 antibodies were detected in the sera from 4.2% (2/48) of patients with autoimmune thyroid disease, including one patient with Hashimoto's thyroiditis (3.7%, 1/27) and one with Graves' disease (4.8%, 1/21). A third patient with pseudohypoparathyroidism, but without thyroid disease, was also positive (1/19; 5.2%). None of 19 patients with differentiated thyroid cancer had anti-p53 antibodies. We conclude that anti-p53 antibodies can be detected in the sera from approximately 4% of patients with autoimmune thyroid disease. This finding suggests that increased DNA damage and apoptosis may be associated with autoimmune thyroid disease.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalAnnals of Clinical and Laboratory Science
Volume30
Issue number2
StatePublished - Apr 1 2000
Externally publishedYes

Keywords

  • Autoimmunity
  • p53
  • Thyroid
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology

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