Autoantibodies to amphiphysin I and amphiphysin II in a patient with sensory-motor neuropathy

L. Perego, S. C. Previtali, R. Nemni, R. Longhi, O. Carandente, A. Saibene, R. Sciolla, A. Villa, P. Gai, C. Panzeri, G. Dell'Antonio, A. Quattrini, F. Folli

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A proportion of patients with peripheral neuropathies has circulating autoantibodies directed against neural antigens. In some cases, autoantibodies may play a pathogenic role. We studied a patient with a progressive sensory-motor axonal neuropathy of unknown etiology, looking for circulating autoantibodies against neural antigens and we showed that the patient's serum contained anti-amphiphysin I (AMP I) and amphiphysin II (AMP II) autoantibodies. A sural nerve biopsy revealed an axonal neuropathy. Indirect immunofluorescence experiments with the patient's serum showed a staining of rat axons due to α-AMP I autoantibodies and a specific labelling of cytoplasm and Schmidt-Lanterman incisures of Schwann cells due to α-AMP II autoantibodies. In conclusion we identified a patient affected by a sensory-motor neuropathy with autoantibodies against both AMP I and AMP II.

Original languageEnglish (US)
Pages (from-to)196-200
Number of pages5
JournalEuropean Neurology
Volume47
Issue number4
DOIs
StatePublished - Jun 22 2002

Keywords

  • Amphiphysin I
  • Amphiphysin II
  • Autoantibodies
  • Neuropathy
  • Peripheral sensory-motor
  • Schmidt-Lanterman incisures

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Perego, L., Previtali, S. C., Nemni, R., Longhi, R., Carandente, O., Saibene, A., Sciolla, R., Villa, A., Gai, P., Panzeri, C., Dell'Antonio, G., Quattrini, A., & Folli, F. (2002). Autoantibodies to amphiphysin I and amphiphysin II in a patient with sensory-motor neuropathy. European Neurology, 47(4), 196-200. https://doi.org/10.1159/000057898