Autoantibodies to amphiphysin I and amphiphysin II in a patient with sensory-motor neuropathy

L. Perego; S. C. Previtali; R. Nemni; R. Longhi; O. Carandente; A. Saibene; R. Sciolla; A. Villa; P. Gai; C. Panzeri; G. Dell'Antonio; A. Quattrini; F. Folli

doi:10.1159/000057898

Autoantibodies to amphiphysin I and amphiphysin II in a patient with sensory-motor neuropathy

L. Perego, S. C. Previtali, R. Nemni, R. Longhi, O. Carandente, A. Saibene, R. Sciolla, A. Villa, P. Gai, C. Panzeri, G. Dell'Antonio, A. Quattrini, F. Folli

Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A proportion of patients with peripheral neuropathies has circulating autoantibodies directed against neural antigens. In some cases, autoantibodies may play a pathogenic role. We studied a patient with a progressive sensory-motor axonal neuropathy of unknown etiology, looking for circulating autoantibodies against neural antigens and we showed that the patient's serum contained anti-amphiphysin I (AMP I) and amphiphysin II (AMP II) autoantibodies. A sural nerve biopsy revealed an axonal neuropathy. Indirect immunofluorescence experiments with the patient's serum showed a staining of rat axons due to α-AMP I autoantibodies and a specific labelling of cytoplasm and Schmidt-Lanterman incisures of Schwann cells due to α-AMP II autoantibodies. In conclusion we identified a patient affected by a sensory-motor neuropathy with autoantibodies against both AMP I and AMP II.

Original language	English (US)
Pages (from-to)	196-200
Number of pages	5
Journal	European Neurology
Volume	47
Issue number	4
DOIs	https://doi.org/10.1159/000057898
State	Published - Jun 22 2002

Keywords

Amphiphysin I
Amphiphysin II
Autoantibodies
Neuropathy
Peripheral sensory-motor
Schmidt-Lanterman incisures

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Autoantibodies to amphiphysin I and amphiphysin II in a patient with sensory-motor neuropathy. / Perego, L.; Previtali, S. C.; Nemni, R.; Longhi, R.; Carandente, O.; Saibene, A.; Sciolla, R.; Villa, A.; Gai, P.; Panzeri, C.; Dell'Antonio, G.; Quattrini, A.; Folli, F.

In: European Neurology, Vol. 47, No. 4, 22.06.2002, p. 196-200.

Research output: Contribution to journal › Article › peer-review

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abstract = "A proportion of patients with peripheral neuropathies has circulating autoantibodies directed against neural antigens. In some cases, autoantibodies may play a pathogenic role. We studied a patient with a progressive sensory-motor axonal neuropathy of unknown etiology, looking for circulating autoantibodies against neural antigens and we showed that the patient's serum contained anti-amphiphysin I (AMP I) and amphiphysin II (AMP II) autoantibodies. A sural nerve biopsy revealed an axonal neuropathy. Indirect immunofluorescence experiments with the patient's serum showed a staining of rat axons due to α-AMP I autoantibodies and a specific labelling of cytoplasm and Schmidt-Lanterman incisures of Schwann cells due to α-AMP II autoantibodies. In conclusion we identified a patient affected by a sensory-motor neuropathy with autoantibodies against both AMP I and AMP II.",

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AU - Previtali, S. C.

AU - Nemni, R.

AU - Longhi, R.

AU - Carandente, O.

AU - Saibene, A.

AU - Sciolla, R.

AU - Villa, A.

AU - Gai, P.

AU - Panzeri, C.

AU - Dell'Antonio, G.

AU - Quattrini, A.

AU - Folli, F.

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AB - A proportion of patients with peripheral neuropathies has circulating autoantibodies directed against neural antigens. In some cases, autoantibodies may play a pathogenic role. We studied a patient with a progressive sensory-motor axonal neuropathy of unknown etiology, looking for circulating autoantibodies against neural antigens and we showed that the patient's serum contained anti-amphiphysin I (AMP I) and amphiphysin II (AMP II) autoantibodies. A sural nerve biopsy revealed an axonal neuropathy. Indirect immunofluorescence experiments with the patient's serum showed a staining of rat axons due to α-AMP I autoantibodies and a specific labelling of cytoplasm and Schmidt-Lanterman incisures of Schwann cells due to α-AMP II autoantibodies. In conclusion we identified a patient affected by a sensory-motor neuropathy with autoantibodies against both AMP I and AMP II.

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