Aureobasidium pullulans var. melanigenum fungemia in a pediatric patient

Kileen L. Mershon-Shier, Jaime G. Deville, Shirley Delair, Annette M Bodi, Brian Wickes, G. Sybren De Hoog, Deanna A. Sutton, Michael A. Lewinski

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

This report describes a chronically ill child who presented with high fever and was diagnosed with catheter-related sepsis. Aureobasidium pullulans variety melanigenum, a dematiaceous fungus that rarely causes opportunistic infections, was recovered from multiple blood cultures. Antifungal susceptibilities were performed and the minimum inhibitory concentration (MIC) for fluconazole was 64 mg/l, suggestive of fluconazole resistance. The patient made a full recovery after removal of the catheter line and treatment with liposomal amphotericin B. This is the first case report of an elevated in vitro fluconazole MIC of an A. pullulans isolate and only the third case of successful treatment of A. pullulans fungemia.

Original languageEnglish (US)
Pages (from-to)80-83
Number of pages4
JournalMedical mycology
Volume49
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • Aureobasidium
  • Fluconazole
  • Fungemia

ASJC Scopus subject areas

  • Infectious Diseases

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