Atypical Case of Bilateral Chandler Syndrome with Recurrent Band Keratopathy

Mamta Agarwal, Richa Dhiman, Krishnakumar Subramanian

Research output: Contribution to journalArticlepeer-review


Purpose:To report a unique case of bilateral Chandler syndrome with recurrent band keratopathy.Methods:This is a retrospective observational case report.Results:A 39-year-old Asian man presented with progressive painless diminution of vision in both eyes for 6 years. Examination revealed diffuse corneal edema, hammered silver appearance of endothelium with guttae-like lesions, and corectopia in the right eye and mild corneal edema, central band keratopathy, and guttae-like lesions on the endothelium and peripheral anterior synechiae in the left eye. Routine specular microscopy, confocal microscopy, and pachymetry were performed. A clinical diagnosis of bilateral Chandler syndrome with band keratopathy was made. Superficial epithelial keratectomy with ethylenediaminetetraacetic acid (EDTA) chelation was performed in the left eye first, followed by Descemet-stripping automated endothelial keratoplasty in the right eye. Histopathological examination of the surgically excised Descemet membrane in the right eye showed multilayered endothelium with adhered epithelial cells consistent with Chandler syndrome. At 9-month follow-up, the right eye showed a clear cornea with an attached graft and the left eye revealed recurrence of central band keratopathy for which repeat EDTA chelation was successfully performed.Conclusions:Recurrent band keratopathy coincident with endothelial dysfunction in iridocorneal endothelial syndrome can be repeatedly treated with EDTA chelation, whereas endothelial keratoplasty might be delayed until the time point of corneal decompensation.

Original languageEnglish (US)
Pages (from-to)1353-1356
Number of pages4
Issue number10
StatePublished - Oct 1 2021
Externally publishedYes


  • band keratopathy
  • Chandler syndrome
  • EDTA chelation
  • endothelial dystrophy
  • iridocorneal endothelial syndrome

ASJC Scopus subject areas

  • Ophthalmology


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