Attenuation of the activity of caspofungin at high concentrations against Candida albicans: Possible role of cell wall integrity and calcineurin pathways

Nathan P. Wiederhold, Dimitrios P. Kontoyiannis, Randall A. Prince, Russell E. Lewis

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

Caspofungin had diminished activity in vitro against Candida albicans at concentrations of 8 to 32 μg/ml. This phenomenon was markedly attenuated in a Δmkc1/Δmkc1 deletion mutant and by the addition of cyclosporine to the wild type. Short exposure to these Caspofungin concentrations resulted in MKC1 upregulation, suggesting roles of cell wall integrity and calcineurin pathways.

Original languageEnglish (US)
Pages (from-to)5146-5148
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume49
Issue number12
DOIs
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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