Attenuation of liver insoluble protein carbonyls

Indicator of a longevity determinant?

Arunabh Bhattacharya, Shanique Leonard, Suzette Tardif, Rochelle Buffenstein, Kathleen E. Fischer, Arlan Richardson, Steven N. Austad, Asish R. Chaudhuri

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Oxidative damage affects protein structure and function. Progressive accumulation of oxidized proteins is considered a putative mechanism of aging; however, empirical evidence supporting their role in aging is inconsistent. This inconsistency may reflect a failure to distinguish damage to particular cellular compartments. We found a significant reduction of protein carbonyls in the insoluble, but not in the soluble, fraction of liver tissues of long-lived compared with their short-lived counterpart. Of cellular components analyzed, only nuclear protein carbonyl level was uniformly reduced in long-lived compared with short-lived animals. This observation suggests that attenuated accumulation of protein carbonyls in the nucleus, where they can affect multiple aspects of gene expression and DNA repair, might contribute to the longevity in mammalian species.

Original languageEnglish (US)
Pages (from-to)720-723
Number of pages4
JournalAging Cell
Volume10
Issue number4
DOIs
StatePublished - Aug 2011

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Liver
Proteins
Nuclear Proteins
DNA Repair
Gene Expression

Keywords

  • Bats
  • Dietary restriction
  • Marmoset
  • Naked mole-rat
  • Oxidative stress
  • Protein carbonylation

ASJC Scopus subject areas

  • Cell Biology
  • Aging

Cite this

Bhattacharya, A., Leonard, S., Tardif, S., Buffenstein, R., Fischer, K. E., Richardson, A., ... Chaudhuri, A. R. (2011). Attenuation of liver insoluble protein carbonyls: Indicator of a longevity determinant? Aging Cell, 10(4), 720-723. https://doi.org/10.1111/j.1474-9726.2011.00712.x

Attenuation of liver insoluble protein carbonyls : Indicator of a longevity determinant? / Bhattacharya, Arunabh; Leonard, Shanique; Tardif, Suzette; Buffenstein, Rochelle; Fischer, Kathleen E.; Richardson, Arlan; Austad, Steven N.; Chaudhuri, Asish R.

In: Aging Cell, Vol. 10, No. 4, 08.2011, p. 720-723.

Research output: Contribution to journalArticle

Bhattacharya, A, Leonard, S, Tardif, S, Buffenstein, R, Fischer, KE, Richardson, A, Austad, SN & Chaudhuri, AR 2011, 'Attenuation of liver insoluble protein carbonyls: Indicator of a longevity determinant?', Aging Cell, vol. 10, no. 4, pp. 720-723. https://doi.org/10.1111/j.1474-9726.2011.00712.x
Bhattacharya A, Leonard S, Tardif S, Buffenstein R, Fischer KE, Richardson A et al. Attenuation of liver insoluble protein carbonyls: Indicator of a longevity determinant? Aging Cell. 2011 Aug;10(4):720-723. https://doi.org/10.1111/j.1474-9726.2011.00712.x
Bhattacharya, Arunabh ; Leonard, Shanique ; Tardif, Suzette ; Buffenstein, Rochelle ; Fischer, Kathleen E. ; Richardson, Arlan ; Austad, Steven N. ; Chaudhuri, Asish R. / Attenuation of liver insoluble protein carbonyls : Indicator of a longevity determinant?. In: Aging Cell. 2011 ; Vol. 10, No. 4. pp. 720-723.
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