Attenuation of liver insoluble protein carbonyls: Indicator of a longevity determinant?

Arunabh Bhattacharya, Shanique Leonard, Suzette Tardif, Rochelle Buffenstein, Kathleen E. Fischer, Arlan Richardson, Steven N. Austad, Asish R. Chaudhuri

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Oxidative damage affects protein structure and function. Progressive accumulation of oxidized proteins is considered a putative mechanism of aging; however, empirical evidence supporting their role in aging is inconsistent. This inconsistency may reflect a failure to distinguish damage to particular cellular compartments. We found a significant reduction of protein carbonyls in the insoluble, but not in the soluble, fraction of liver tissues of long-lived compared with their short-lived counterpart. Of cellular components analyzed, only nuclear protein carbonyl level was uniformly reduced in long-lived compared with short-lived animals. This observation suggests that attenuated accumulation of protein carbonyls in the nucleus, where they can affect multiple aspects of gene expression and DNA repair, might contribute to the longevity in mammalian species.

Original languageEnglish (US)
Pages (from-to)720-723
Number of pages4
JournalAging cell
Issue number4
StatePublished - Aug 2011


  • Bats
  • Dietary restriction
  • Marmoset
  • Naked mole-rat
  • Oxidative stress
  • Protein carbonylation

ASJC Scopus subject areas

  • Aging
  • Cell Biology


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