Attenuation correction of equilibrium radionuclide angiography for noninvasive quantitation of cardiac output and ventricular volumes

Michael A. Petru, Sherman G. Sorensen, Tuhin K. Chaudhuri, Paul Rosen, Robert A. O'Rourke

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Gated equilibrium radionuclide angiography (RNA) provides count information which is proportional to ventricular volumes. In order to convert ventricular count data directly to accurate absolute volumes, we performed attenuation correction on equilibrium radionuclide angiograms by means of a simple geometric method of attenuation distance quantitation. Attenuation distance defined during imaging agreed with similar measurements obtained during fluoroscopy (r = 0.86). In seven patients, 23 simultaneous cardiac output determinations by Fick and radionuclide imaging techniques showed excellent correlation over a wide range of cardiac outputs (r = 0.91). Radionuclide angiographic ventricular volumes correlated with contrast angiographic ventricular volumes in 28 patients (r = 0.80). The weaker correlation found for ventricular volume data may be due to inaccuracies in ventricular volume calculation when single-plane contrast angiography is applied to patients with wall motion abnormalities. We conclude that attenuation-corrected RNA allows direct calculation of cardiac output and ventricular volumes in individual patients without use of regression equations.

Original languageEnglish (US)
Pages (from-to)1221-1228
Number of pages8
JournalAmerican Heart Journal
Volume107
Issue number6
DOIs
StatePublished - Jun 1984

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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