Abstract
If thyroparathyroidectomized or parathyroidectomized (PTX) immature male rats are pinealectomized (PX) most (approx. 80%) of them experience numerous convulsive seizures within 8 hr after removal of the pineal gland. The postconvulsive mortality (by 48 hr after pinealectomy) is about 30%. Other surgical procedures involving opening of the skull, such as olfactory bulbectomy or unilateral transection of the nervi conarii, do not initiate convulsions in PTX rats. Likewise, denervation of the pineal gland by superior cervical ganglionectomy (SCGX) in PTX rats is not followed by seizures. However, if PTX + SCGX rats are subsequently subjected to pineal gland removal they experience the convulsions. This latter finding suggests that the pineal gland may remain functional after sympathetic denervation. The injection of calcium lactate does not protect against the seizures in PTX + PX rats. If the operations are reversed, i.e., if pineal gland removal precedes PTX by one week the rats do not exhibit the convulsive behavior. Whole brain norepinephrine is depressed in convulsing rats while serotonin and dopamine levels remain unchanged.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 203-208 |
| Number of pages | 6 |
| Journal | Physiology and Behavior |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1972 |
| Externally published | Yes |
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Keywords
- Convulsions
- Norepinephrine
- Parathyroid glands
- Pineal gland
- Pineal innervation
- Pinealectomy
- Thyroparathyroidectomy
ASJC Scopus subject areas
- Physiology (medical)
- Behavioral Neuroscience
Cite this
Attempts to characterize the convulsive response of parathyroidectomized rats to pineal gland removal. / Reiter, Russel J; Morgan, William W.
In: Physiology and Behavior, Vol. 9, No. 2, 1972, p. 203-208.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Attempts to characterize the convulsive response of parathyroidectomized rats to pineal gland removal
AU - Reiter, Russel J
AU - Morgan, William W.
PY - 1972
Y1 - 1972
N2 - If thyroparathyroidectomized or parathyroidectomized (PTX) immature male rats are pinealectomized (PX) most (approx. 80%) of them experience numerous convulsive seizures within 8 hr after removal of the pineal gland. The postconvulsive mortality (by 48 hr after pinealectomy) is about 30%. Other surgical procedures involving opening of the skull, such as olfactory bulbectomy or unilateral transection of the nervi conarii, do not initiate convulsions in PTX rats. Likewise, denervation of the pineal gland by superior cervical ganglionectomy (SCGX) in PTX rats is not followed by seizures. However, if PTX + SCGX rats are subsequently subjected to pineal gland removal they experience the convulsions. This latter finding suggests that the pineal gland may remain functional after sympathetic denervation. The injection of calcium lactate does not protect against the seizures in PTX + PX rats. If the operations are reversed, i.e., if pineal gland removal precedes PTX by one week the rats do not exhibit the convulsive behavior. Whole brain norepinephrine is depressed in convulsing rats while serotonin and dopamine levels remain unchanged.
AB - If thyroparathyroidectomized or parathyroidectomized (PTX) immature male rats are pinealectomized (PX) most (approx. 80%) of them experience numerous convulsive seizures within 8 hr after removal of the pineal gland. The postconvulsive mortality (by 48 hr after pinealectomy) is about 30%. Other surgical procedures involving opening of the skull, such as olfactory bulbectomy or unilateral transection of the nervi conarii, do not initiate convulsions in PTX rats. Likewise, denervation of the pineal gland by superior cervical ganglionectomy (SCGX) in PTX rats is not followed by seizures. However, if PTX + SCGX rats are subsequently subjected to pineal gland removal they experience the convulsions. This latter finding suggests that the pineal gland may remain functional after sympathetic denervation. The injection of calcium lactate does not protect against the seizures in PTX + PX rats. If the operations are reversed, i.e., if pineal gland removal precedes PTX by one week the rats do not exhibit the convulsive behavior. Whole brain norepinephrine is depressed in convulsing rats while serotonin and dopamine levels remain unchanged.
KW - Convulsions
KW - Norepinephrine
KW - Parathyroid glands
KW - Pineal gland
KW - Pineal innervation
KW - Pinealectomy
KW - Thyroparathyroidectomy
UR - http://www.scopus.com/inward/record.url?scp=0015376906&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015376906&partnerID=8YFLogxK
U2 - 10.1016/0031-9384(72)90236-3
DO - 10.1016/0031-9384(72)90236-3
M3 - Article
C2 - 4654733
AN - SCOPUS:0015376906
VL - 9
SP - 203
EP - 208
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
IS - 2
ER -