TY - JOUR
T1 - Atrial Fibrillation Is Associated With Lower Cognitive Performance in the Framingham Offspring Men
AU - Elias, Merrill F.
AU - Sullivan, Lisa M.
AU - Elias, Penelope K.
AU - Vasan, Ramachandran S.
AU - D'Agostino, Ralph B.
AU - Seshadri, Sudha
AU - Au, Rhoda
AU - Wolf, Philip A.
AU - Benjamin, Emelia J.
N1 - Funding Information:
Supported by the National Heart, Lung, and Blood Institute (NHLBI)’s Framingham Heart Study; the National Institutes of Health (NIH)/NHLBI contract NO1-HC-25195; NIH/National Institute on Aging (NIA) grant 5RO1-AGO8122; NIH/NIA grant 5RO1-AG16495; NIH/National Institute of Neurological Disorders and Stroke grant 5RO1-NS17950; NIH/NHLBI grant NO1-HC-25195; NIH/NHLBI grant 1RO1-HL081290; NIH/NHLBI grant 1RO1-HL67358; the Boston University Alzheimer’s Disease Center (grant P30 AG13846); and a midcareer investigator award NIH (2K24HL004334) (Dr. Vasan).
PY - 2006/9/10
Y1 - 2006/9/10
N2 - The purpose of this study was to investigate the association of atrial fibrillation (AFIB) with multiple measures of cognitive performance in a large community-based sample extensively characterized for vascular risk factors. Our primary analysis included 1011 Framingham Offspring Study (Framingham, Mass) men, mean age = 61.0 (37-89) years, free of clinical stroke and dementia. Using multivariable linear regression models, we related the presence (n = 59) versus absence (n = 952) of AFIB in men to a global measure of performance and multiple measures of specific cognitive abilities assessed an average of 8 months after the AFIB surveillance period. Adjusting for age, education, multiple cardiovascular risk factors, and cardiovascular disease, men with AFIB exhibited significantly lower mean levels of cognitive performance compared with men in normal sinus rhythm. Men with AFIB exhibited lower performance on global cognitive ability and cognitive abilities including Similarities (abstract reasoning), Visual Reproductions-Immediate Recall, Visual Reproductions-Delayed Recall, Visual Organization, Logical Memory-Delayed Recall, and Trail Making A (scanning and tracking) and Trail Making B (scanning, tracking, and executive functioning). Further studies leading to a better understanding of the mechanisms underlying the relation between AFIB and cognitive performance are important.
AB - The purpose of this study was to investigate the association of atrial fibrillation (AFIB) with multiple measures of cognitive performance in a large community-based sample extensively characterized for vascular risk factors. Our primary analysis included 1011 Framingham Offspring Study (Framingham, Mass) men, mean age = 61.0 (37-89) years, free of clinical stroke and dementia. Using multivariable linear regression models, we related the presence (n = 59) versus absence (n = 952) of AFIB in men to a global measure of performance and multiple measures of specific cognitive abilities assessed an average of 8 months after the AFIB surveillance period. Adjusting for age, education, multiple cardiovascular risk factors, and cardiovascular disease, men with AFIB exhibited significantly lower mean levels of cognitive performance compared with men in normal sinus rhythm. Men with AFIB exhibited lower performance on global cognitive ability and cognitive abilities including Similarities (abstract reasoning), Visual Reproductions-Immediate Recall, Visual Reproductions-Delayed Recall, Visual Organization, Logical Memory-Delayed Recall, and Trail Making A (scanning and tracking) and Trail Making B (scanning, tracking, and executive functioning). Further studies leading to a better understanding of the mechanisms underlying the relation between AFIB and cognitive performance are important.
KW - Atrial fibrillation-cognition-cognitive performance-male-cardiovascular diseases-cardiovascular epidemiology
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U2 - 10.1016/j.jstrokecerebrovasdis.2006.05.009
DO - 10.1016/j.jstrokecerebrovasdis.2006.05.009
M3 - Article
C2 - 17904078
AN - SCOPUS:33748455067
VL - 15
SP - 214
EP - 222
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
SN - 1052-3057
IS - 5
ER -