Atherosclerosis-related responses to cigarette smoking in the baboon

W. R. Rogers, R. L. Bass, D. E. Johnson, A. W. Kruski, C. A. McMahan, M. M. Montiel, G. E. Mott, R. L. Wilbur, H. C. McGill

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Thirty-six young adult male baboons (Papio cynocephalus) were fed an atherogenic diet (40% calories from lard, 1.5 mg cholesterol/kcal) and taught to puff by operant conditioning with water rewards. Eighteen baboons (smokers) were assigned randomly to smoke 43 cigarettes a day, and 18 baboons (shams) were assigned randomly to puff air under conditions equivalent to those of the experimental group. During months 14-19 of smoking, cigarette-smoking baboons had significantly higher carbon monoxide and thiocyanate concentrations in blood and cotinine concentrations in urine. There were no significant differences in serum total cholesterol, VLDL + LDL cholesterol or triglyceride concentrations of smokers and shams. Smoking baboons had significantly higher fasting blood glucose concentrations and lymphocyte counts. Platelet count, platelet aggregation, food and water intake, and body weight were not significantly different in the two groups.

Original languageEnglish (US)
Pages (from-to)1188-1193
Number of pages6
JournalCirculation
Volume61
Issue number6
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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