Atherosclerosis in youth

H. C. McGill, E. E. Herderick, C. A. McMahan, A. W. Zieske, G. T. Malcom, R. E. Tracy, J. P. Strong

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)437-447
Number of pages11
JournalMinerva Pediatrica
Volume54
Issue number5
StatePublished - Oct 2002

Fingerprint

Coronary Disease
Atherosclerosis
Blood Glucose
Coronary Vessels
Obesity
Smoking
Renal Hypertension
Abdominal Aorta
Renal Artery
Primary Prevention
Developed Countries
HDL Cholesterol
Developing Countries
Lipoproteins
Multicenter Studies
Aorta
Body Mass Index
Public Health
Arteries
Erythrocytes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

McGill, H. C., Herderick, E. E., McMahan, C. A., Zieske, A. W., Malcom, G. T., Tracy, R. E., & Strong, J. P. (2002). Atherosclerosis in youth. Minerva Pediatrica, 54(5), 437-447.

Atherosclerosis in youth. / McGill, H. C.; Herderick, E. E.; McMahan, C. A.; Zieske, A. W.; Malcom, G. T.; Tracy, R. E.; Strong, J. P.

In: Minerva Pediatrica, Vol. 54, No. 5, 10.2002, p. 437-447.

Research output: Contribution to journalArticle

McGill, HC, Herderick, EE, McMahan, CA, Zieske, AW, Malcom, GT, Tracy, RE & Strong, JP 2002, 'Atherosclerosis in youth', Minerva Pediatrica, vol. 54, no. 5, pp. 437-447.
McGill HC, Herderick EE, McMahan CA, Zieske AW, Malcom GT, Tracy RE et al. Atherosclerosis in youth. Minerva Pediatrica. 2002 Oct;54(5):437-447.
McGill, H. C. ; Herderick, E. E. ; McMahan, C. A. ; Zieske, A. W. ; Malcom, G. T. ; Tracy, R. E. ; Strong, J. P. / Atherosclerosis in youth. In: Minerva Pediatrica. 2002 ; Vol. 54, No. 5. pp. 437-447.
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title = "Atherosclerosis in youth",
abstract = "Background. Coronary heart disease (CHD) and the related diseases due to atherosclerosis continue to be major public health problems in the industrialized countries and are likely to become serious problems in the developing countries. Treatment of end stage disease has improved, and risk factor modification has succeeded in reducing risk among adults. However, the age at which to begin risk factor control for long-range primary prevention is controversial. Methods. A multicenter cooperative study, Pathobiological Determinants of Atherosclerosis in Youth (PDAY), was organized in 1985 to examine the relationship of the risk factors for adult CHD to preclinical atherosclerotic lesions in youth. Fourteen participating centers collected arteries, blood, other tissue, and data from 3,000 persons 15-34 years of age who died from external causes and were autopsied in forensic laboratories. Central laboratories evaluated atherosclerosiis in the aorta and coronary arteries, measured lipoproteins and thiocyanate (for smoking) in serum, glycohemoglobin in red blood cells (for blood glucose), thickness of small renal arteries (for hypertension), and body mass index (for obesity). The data were analyzed to determine the progression of atherosclerosis with age in both sexes and the association of the risk factors with atherosclerotic lesions. Results. Raised lesions of the coronary arteries, the advanced lesions of atherosclerosis that lead directly to CHD, are associated positively with non-HDL cholesterol concentration, hypertension, obesity (in men), and blood glucose concentration; and inversely, with HDL cholesterol concentration. Smoking affects predominantly the abdominal aorta. Conclusions. These results suggest that long-range prevention of CHD should begin in adolescence or at least in young adulthood with control of the major established risk factors for adult CHD.",
keywords = "Atherosclerosis, Coronary diseases, etiology, Risk factors",
author = "McGill, {H. C.} and Herderick, {E. E.} and McMahan, {C. A.} and Zieske, {A. W.} and Malcom, {G. T.} and Tracy, {R. E.} and Strong, {J. P.}",
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T1 - Atherosclerosis in youth

AU - McGill, H. C.

AU - Herderick, E. E.

AU - McMahan, C. A.

AU - Zieske, A. W.

AU - Malcom, G. T.

AU - Tracy, R. E.

AU - Strong, J. P.

PY - 2002/10

Y1 - 2002/10

N2 - Background. Coronary heart disease (CHD) and the related diseases due to atherosclerosis continue to be major public health problems in the industrialized countries and are likely to become serious problems in the developing countries. Treatment of end stage disease has improved, and risk factor modification has succeeded in reducing risk among adults. However, the age at which to begin risk factor control for long-range primary prevention is controversial. Methods. A multicenter cooperative study, Pathobiological Determinants of Atherosclerosis in Youth (PDAY), was organized in 1985 to examine the relationship of the risk factors for adult CHD to preclinical atherosclerotic lesions in youth. Fourteen participating centers collected arteries, blood, other tissue, and data from 3,000 persons 15-34 years of age who died from external causes and were autopsied in forensic laboratories. Central laboratories evaluated atherosclerosiis in the aorta and coronary arteries, measured lipoproteins and thiocyanate (for smoking) in serum, glycohemoglobin in red blood cells (for blood glucose), thickness of small renal arteries (for hypertension), and body mass index (for obesity). The data were analyzed to determine the progression of atherosclerosis with age in both sexes and the association of the risk factors with atherosclerotic lesions. Results. Raised lesions of the coronary arteries, the advanced lesions of atherosclerosis that lead directly to CHD, are associated positively with non-HDL cholesterol concentration, hypertension, obesity (in men), and blood glucose concentration; and inversely, with HDL cholesterol concentration. Smoking affects predominantly the abdominal aorta. Conclusions. These results suggest that long-range prevention of CHD should begin in adolescence or at least in young adulthood with control of the major established risk factors for adult CHD.

AB - Background. Coronary heart disease (CHD) and the related diseases due to atherosclerosis continue to be major public health problems in the industrialized countries and are likely to become serious problems in the developing countries. Treatment of end stage disease has improved, and risk factor modification has succeeded in reducing risk among adults. However, the age at which to begin risk factor control for long-range primary prevention is controversial. Methods. A multicenter cooperative study, Pathobiological Determinants of Atherosclerosis in Youth (PDAY), was organized in 1985 to examine the relationship of the risk factors for adult CHD to preclinical atherosclerotic lesions in youth. Fourteen participating centers collected arteries, blood, other tissue, and data from 3,000 persons 15-34 years of age who died from external causes and were autopsied in forensic laboratories. Central laboratories evaluated atherosclerosiis in the aorta and coronary arteries, measured lipoproteins and thiocyanate (for smoking) in serum, glycohemoglobin in red blood cells (for blood glucose), thickness of small renal arteries (for hypertension), and body mass index (for obesity). The data were analyzed to determine the progression of atherosclerosis with age in both sexes and the association of the risk factors with atherosclerotic lesions. Results. Raised lesions of the coronary arteries, the advanced lesions of atherosclerosis that lead directly to CHD, are associated positively with non-HDL cholesterol concentration, hypertension, obesity (in men), and blood glucose concentration; and inversely, with HDL cholesterol concentration. Smoking affects predominantly the abdominal aorta. Conclusions. These results suggest that long-range prevention of CHD should begin in adolescence or at least in young adulthood with control of the major established risk factors for adult CHD.

KW - Atherosclerosis

KW - Coronary diseases, etiology

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