Associations of the Mediterranean-DASH Intervention for Neurodegenerative Delay Diet with cardiac remodeling in the community: The Framingham Heart Study

Maura E. Walker, Adrienne A. O'Donnell, Jayandra J. Himali, Iniya Rajendran, Debora Melo Van Lent, Feven Ataklte, Paul F. Jacques, Alexa S. Beiser, Sudha Seshadri, Ramachandran S. Vasan, Vanessa Xanthakis

Research output: Contribution to journalArticlepeer-review

Abstract

Normal cardiac function is directly associated with the maintenance of cerebrovascular health. Whether the Mediterranean-Dietary Approach to Systolic Hypertension Intervention for Neurodegenerative Delay (MIND) diet, designed for the maintenance of neurocognitive health, is associated with cardiac remodeling is unknown. We evaluated 2512 Framingham Offspring Cohort participants who attended the 8th examination cycle and had available dietary and echocardiographic data (mean age 66 years; 55% women). Using multivariable regression, we related the cumulative MIND diet score (independent variable) to left ventricular (LV) ejection fraction, left atrial emptying fraction, LV mass (LVM), E/e' ratio (dependent variables; primary), global longitudinal strain, global circumferential strain (GCS), mitral annular plane systolic excursion, longitudinal segmental synchrony, LV hypertrophy, and aortic root diameter (secondary). Adjusting for age, sex, and energy intake, higher cumulative MIND diet scores were associated with lower values of indices of LV diastolic (E/e' ratio: logβ=-0.03) and systolic function (GCS: β=-0.04), and with higher values of LVM (logβ=0.02), all P≤0.01. We observed effect modification by age in the association between the cumulative MIND diet score and GCS. When we further adjusted for clinical risk factors, the associations of the cumulative MIND diet score with GCS in participants ≥66 years (β=-0.06, P=0.005) and LVM remained significant. In our community-based sample, relations between the cumulative MIND diet score and cardiac remodeling differ among indices of LV structure and function. Our results suggest that favorable associations between a higher cumulative MIND diet score and indices of LV function may be influenced by cardiometabolic and lifestyle risk factors.

Original languageEnglish (US)
JournalBritish Journal of Nutrition
DOIs
StateAccepted/In press - 2021

Keywords

  • cardiac remodeling
  • left ventricular function
  • left ventricular structure
  • MIND diet

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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