Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study

Heidi I.L. Jacobs; Adrienne O'donnell; Claudia L. Satizabal; Cristina Lois; Daniel Kojis; Bernard J. Hanseeuw; Emma Thibault; Justin S. Sanchez; Rachel F. Buckley; Qiong Yang; Charles Decarli; Ron Killiany; Muralidharan Sargurupremraj; Reisa A. Sperling; Keith A. Johnson; Alexa S. Beiser; Sudha Seshadri

doi:10.3233/JAD-215372

Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study

Heidi I.L. Jacobs, Adrienne O'donnell, Claudia L. Satizabal, Cristina Lois, Daniel Kojis, Bernard J. Hanseeuw, Emma Thibault, Justin S. Sanchez, Rachel F. Buckley, Qiong Yang, Charles Decarli, Ron Killiany, Muralidharan Sargurupremraj, Reisa A. Sperling, Keith A. Johnson, Alexa S. Beiser, Sudha Seshadri

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1 Scopus citations

Abstract

The brainstem is among the first regions to accumulate Alzheimer's disease (AD)-related hyperphosphorylated tau pathology during aging. We aimed to examine associations between brainstem volume and neocortical amyloid-β or tau pathology in 271 middle-aged clinically normal individuals of the Framingham Heart Study who underwent MRI and PET imaging. Lower volume of the medulla, pons, or midbrain was associated with greater neocortical amyloid burden. No associations were detected between brainstem volumes and tau deposition. Our results support the hypothesis that lower brainstem volumes are associated with initial AD-related processes and may signal preclinical AD pathology.

Original language	English (US)
Pages (from-to)	1603-1609
Number of pages	7
Journal	Journal of Alzheimer's Disease
Volume	86
Issue number	4
DOIs	https://doi.org/10.3233/JAD-215372
State	Published - 2022

Keywords

Aging
amyloid
brainstem
tau

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/JAD-215372

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Jacobs, H. I. L., O'donnell, A., Satizabal, C. L., Lois, C., Kojis, D., Hanseeuw, B. J., Thibault, E., Sanchez, J. S., Buckley, R. F., Yang, Q., Decarli, C., Killiany, R., Sargurupremraj, M., Sperling, R. A., Johnson, K. A., Beiser, A. S., & Seshadri, S. (2022). Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study. Journal of Alzheimer's Disease, 86(4), 1603-1609. https://doi.org/10.3233/JAD-215372

Jacobs, HIL, O'donnell, A, Satizabal, CL, Lois, C, Kojis, D, Hanseeuw, BJ, Thibault, E, Sanchez, JS, Buckley, RF, Yang, Q, Decarli, C, Killiany, R, Sargurupremraj, M, Sperling, RA, Johnson, KA, Beiser, AS & Seshadri, S 2022, 'Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study', Journal of Alzheimer's Disease, vol. 86, no. 4, pp. 1603-1609. https://doi.org/10.3233/JAD-215372

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title = "Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study",

abstract = "The brainstem is among the first regions to accumulate Alzheimer's disease (AD)-related hyperphosphorylated tau pathology during aging. We aimed to examine associations between brainstem volume and neocortical amyloid-β or tau pathology in 271 middle-aged clinically normal individuals of the Framingham Heart Study who underwent MRI and PET imaging. Lower volume of the medulla, pons, or midbrain was associated with greater neocortical amyloid burden. No associations were detected between brainstem volumes and tau deposition. Our results support the hypothesis that lower brainstem volumes are associated with initial AD-related processes and may signal preclinical AD pathology.",

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AU - Jacobs, Heidi I.L.

AU - O'donnell, Adrienne

AU - Satizabal, Claudia L.

AU - Lois, Cristina

AU - Kojis, Daniel

AU - Hanseeuw, Bernard J.

AU - Thibault, Emma

AU - Sanchez, Justin S.

AU - Buckley, Rachel F.

AU - Yang, Qiong

AU - Decarli, Charles

AU - Killiany, Ron

AU - Sargurupremraj, Muralidharan

AU - Sperling, Reisa A.

AU - Johnson, Keith A.

AU - Beiser, Alexa S.

AU - Seshadri, Sudha

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AB - The brainstem is among the first regions to accumulate Alzheimer's disease (AD)-related hyperphosphorylated tau pathology during aging. We aimed to examine associations between brainstem volume and neocortical amyloid-β or tau pathology in 271 middle-aged clinically normal individuals of the Framingham Heart Study who underwent MRI and PET imaging. Lower volume of the medulla, pons, or midbrain was associated with greater neocortical amyloid burden. No associations were detected between brainstem volumes and tau deposition. Our results support the hypothesis that lower brainstem volumes are associated with initial AD-related processes and may signal preclinical AD pathology.

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KW - brainstem

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Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study

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