Associations among 5-year changes in weight, physical activity, and cardiovascular disease risk factors in Mexican Americans

David L. Rainwater, Braxton D. Mitchell, Anthony G. Comuzzie, John L. VandeBerg, Michael P. Stern, Jean W. MacCluer

    Research output: Contribution to journalArticlepeer-review

    32 Scopus citations


    Recent changes in lifestyle have led to a global epidemic of obesity. To determine the associations of these changes with cardiovascular disease (CVD) risk, the authors correlated changes in CVD risk factors with changes in weight and physical activity in a population-based sample of 539 Mexican Americans in the San Antonio Heart Study in 1992-1999 who were examined twice approximately 5 years apart. Average weight change during that interval was 2.7 kg. While change in physical activity (expressed as percent change) was associated modestly only with change in low density lipoprotein cholesterol median diameter (p = 0.017), weight change was strongly and positively associated with unfavorable changes in lipid and lipoprotein traits, insulin levels, and blood pressure, explaining 2-10% of the variation in the risk factor changes during the interval. The unfavorable associations with weight gain tended to be more pronounced in lean compared with obese individuals and in men compared with women. However, the associations were significant for most CVD risk factors in all groups. In Mexican Americans, a population at high risk for obesity, weight change was positively correlated with metabolic variables associated with risk of CVD. Therefore, increasing adiposity in this population may tend to slow, or even reverse, the decline in CVD morbidity and mortality.

    Original languageEnglish (US)
    Pages (from-to)974-982
    Number of pages9
    JournalAmerican journal of epidemiology
    Issue number10
    StatePublished - Nov 15 2000


    • Lipoproteins
    • Mexican Americans
    • Obesity
    • Risk factors

    ASJC Scopus subject areas

    • Epidemiology

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