Association study of T102C 5-HT2A polymorphism in schizophrenic patients: Diagnosis, psychopathology, and suicidal behavior

Humberto Correa, Luiz De Marco, Wolfanga Boson, Rodrigo Nicolato, António L. Teixeira, Valdir R. Campo, Marco A. Romano-Silva

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The objective of this study was to examine the association between the serotonin (5-HT)2A gene polymorphism (102T/C) and suicidal behavior in schizophrenic inpatients. We studied 129 subjects who met the diagnostic criteria for schizophrenia according to a structured clinical interview (MINI-PLUS). Patients underwent a semistructured interview to assess suicide attempt history and its characteristics. In addition, at least one close relative of the patient was interviewed to assess proband and family suicidal behavior. Healthy controls were students and hospital staff members free of psychiatric and medical illness. Genotypes were determined after polymerase chain reaction amplification of the region of 5-HT2A/T102C containing the polymorphic site and digestion with the restriction enzyme Hpall. We found no association between suicidal attempt history and suicide attempt characteristics and genotypic or allele frequencies. Suicidal behavior was also not associated with demographic or psychopathological characteristics. These results suggest that the 5-HT2A gene polymorphism (102T/C) is not involved in genetic susceptibility to suicidal behavior, but further studies in a larger sample are needed.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalDialogues in Clinical Neuroscience
Volume9
Issue number1
StatePublished - 2007
Externally publishedYes

Keywords

  • 5-HT
  • Polymorphism
  • Schizophrenia
  • Suicide

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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