Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese

Peng Zhang, Ze Yang, Chuanfang Zhang, Zeping Lu, Xiaohong Shi, Weidong Zheng, Chunling Wan, Duanyang Zhang, Chenguang Zheng, Shu Li, Feng Jin, Li Wang

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

To investigate the possible involvement of the transferrin (TF) gene polymorphism in the manifestation of Alzheimer's disease (AD), we analyzed the TF and apolipoprotein E (APOE) genotypes of 67 sporadic late-onset AD patients and 131 normal elderly controls in the Chinese population. Our data showed that the TF C1 homozygosity carriers had an increased risk of AD in subjects ≥75 years of age, showing that homozygosity for the TF C1 allele was associated with an approximately three-fold increased risk (OR=3.57, 95% CI, 1.24-10.27, P=0.014). No synergic effects were found between the APOE ε4 allele and TF gene polymorphisms.

Original languageEnglish (US)
Pages (from-to)209-211
Number of pages3
JournalNeuroscience Letters
Volume349
Issue number3
DOIs
StatePublished - Oct 9 2003
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Chinese
  • Gene polymorphisms
  • Transferrin

ASJC Scopus subject areas

  • Neuroscience(all)

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