Abstract
To investigate the possible involvement of the transferrin (TF) gene polymorphism in the manifestation of Alzheimer's disease (AD), we analyzed the TF and apolipoprotein E (APOE) genotypes of 67 sporadic late-onset AD patients and 131 normal elderly controls in the Chinese population. Our data showed that the TF C1 homozygosity carriers had an increased risk of AD in subjects ≥75 years of age, showing that homozygosity for the TF C1 allele was associated with an approximately three-fold increased risk (OR=3.57, 95% CI, 1.24-10.27, P=0.014). No synergic effects were found between the APOE ε4 allele and TF gene polymorphisms.
Original language | English (US) |
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Pages (from-to) | 209-211 |
Number of pages | 3 |
Journal | Neuroscience Letters |
Volume | 349 |
Issue number | 3 |
DOIs | |
State | Published - Oct 9 2003 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Apolipoprotein E
- Chinese
- Gene polymorphisms
- Transferrin
ASJC Scopus subject areas
- General Neuroscience