Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P

Allison K. Rodgers, Jie Wang, Yingqian Zhang, Alan Holden, Blake Berryhill, Nicole M. Budrys, Robert S. Schenken, Guangming Zhong

Research output: Contribution to journalArticle

45 Scopus citations


Objective: The objective of the study was to assess antibodies against Chlamydia trachomatis heat shock proteins (HSP) in patients with tubal factor infertility (TFI), infertility controls (IFC), and fertile controls (FC). HSPs assist organisms in surviving caustic environments such as heat. Study design: Twenty-one TFI, 15 IFC, and 29 FC patients were enrolled after laparoscopic tubal assessment. The titers of antibodies against C trachomatis organisms and 14 chlamydial HSPs were compared among the 3 groups. Results: TFI patients developed significantly higher levels of antibodies against C trachomatis and specifically recognizing chlamydial HSP60 and caseinolytic protease (Clp) P, a subunit of the ATP-dependent Clp protease complex involved in the degradation of abnormal proteins. Conclusion: In addition to confirming high titers of antibodies against C trachomatis organisms and HSP60 in TFI patients, we identified a novel link of TFI with anti-ClpP antibodies. These findings may provide useful information for developing a noninvasive screening test for TFI and constructing subunit anti-C trachomatis vaccines.

Original languageEnglish (US)
Pages (from-to)494.e7-494.e14
JournalAmerican Journal of Obstetrics and Gynecology
Issue number5
StatePublished - Nov 2010



  • Chlamydia trachomatis
  • antibodies to caseinolytic protease P
  • heat shock protein
  • tubal factor infertility

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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