Association of the TNF2 allele with eclampsia

Thomas Kaiser; Madonna Grehan; Shaun P. Brennecke; Eric K. Moses

doi:10.1159/000076689

Association of the TNF2 allele with eclampsia

Thomas Kaiser, Madonna Grehan, Shaun P. Brennecke, Eric K. Moses

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The genetic background predisposing pregnant women to the disorder pre-eclampsia/eclampsia (PE/E) is still unknown. There is compelling evidence to suspect involvement of the immune system in the development of PE/E. The aim of this current study was to investigate whether there is an association between the tumor necrosis factor (TNF)-α -307 polymorphism and PE or eclampsia. In this study, 51 cases of eclampsia, 122 cases of PE and 100 normotensive control cases were genotyped for the TNF-α -307 polymorphism. We found a significant difference between the TNF2 allele frequencies of eclamptic and normotensive controls (χ² = 6.3 and p = 0.025), but not of pre-eclamptic and normotensive controls (χ² = 0.5 and p = 1.0). We conclude from this study that the TNF2 allele contributes to the occurrence of eclampsia in our population.

Original language	English (US)
Pages (from-to)	204-209
Number of pages	6
Journal	Gynecologic and Obstetric Investigation
Volume	57
Issue number	4
DOIs	https://doi.org/10.1159/000076689
State	Published - 2004

Keywords

Eclampsia
Pre-eclampsia
TNF-α -307 polymorphism

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1159/000076689

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title = "Association of the TNF2 allele with eclampsia",

abstract = "The genetic background predisposing pregnant women to the disorder pre-eclampsia/eclampsia (PE/E) is still unknown. There is compelling evidence to suspect involvement of the immune system in the development of PE/E. The aim of this current study was to investigate whether there is an association between the tumor necrosis factor (TNF)-α -307 polymorphism and PE or eclampsia. In this study, 51 cases of eclampsia, 122 cases of PE and 100 normotensive control cases were genotyped for the TNF-α -307 polymorphism. We found a significant difference between the TNF2 allele frequencies of eclamptic and normotensive controls (χ2 = 6.3 and p = 0.025), but not of pre-eclamptic and normotensive controls (χ2 = 0.5 and p = 1.0). We conclude from this study that the TNF2 allele contributes to the occurrence of eclampsia in our population.",

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AU - Kaiser, Thomas

AU - Grehan, Madonna

AU - Brennecke, Shaun P.

AU - Moses, Eric K.

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N2 - The genetic background predisposing pregnant women to the disorder pre-eclampsia/eclampsia (PE/E) is still unknown. There is compelling evidence to suspect involvement of the immune system in the development of PE/E. The aim of this current study was to investigate whether there is an association between the tumor necrosis factor (TNF)-α -307 polymorphism and PE or eclampsia. In this study, 51 cases of eclampsia, 122 cases of PE and 100 normotensive control cases were genotyped for the TNF-α -307 polymorphism. We found a significant difference between the TNF2 allele frequencies of eclamptic and normotensive controls (χ2 = 6.3 and p = 0.025), but not of pre-eclamptic and normotensive controls (χ2 = 0.5 and p = 1.0). We conclude from this study that the TNF2 allele contributes to the occurrence of eclampsia in our population.

AB - The genetic background predisposing pregnant women to the disorder pre-eclampsia/eclampsia (PE/E) is still unknown. There is compelling evidence to suspect involvement of the immune system in the development of PE/E. The aim of this current study was to investigate whether there is an association between the tumor necrosis factor (TNF)-α -307 polymorphism and PE or eclampsia. In this study, 51 cases of eclampsia, 122 cases of PE and 100 normotensive control cases were genotyped for the TNF-α -307 polymorphism. We found a significant difference between the TNF2 allele frequencies of eclamptic and normotensive controls (χ2 = 6.3 and p = 0.025), but not of pre-eclamptic and normotensive controls (χ2 = 0.5 and p = 1.0). We conclude from this study that the TNF2 allele contributes to the occurrence of eclampsia in our population.

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