Association of the TNF2 allele with eclampsia

Thomas Kaiser, Madonna Grehan, Shaun P. Brennecke, Eric K. Moses

    Research output: Contribution to journalArticlepeer-review

    21 Scopus citations

    Abstract

    The genetic background predisposing pregnant women to the disorder pre-eclampsia/eclampsia (PE/E) is still unknown. There is compelling evidence to suspect involvement of the immune system in the development of PE/E. The aim of this current study was to investigate whether there is an association between the tumor necrosis factor (TNF)-α -307 polymorphism and PE or eclampsia. In this study, 51 cases of eclampsia, 122 cases of PE and 100 normotensive control cases were genotyped for the TNF-α -307 polymorphism. We found a significant difference between the TNF2 allele frequencies of eclamptic and normotensive controls (χ2 = 6.3 and p = 0.025), but not of pre-eclamptic and normotensive controls (χ2 = 0.5 and p = 1.0). We conclude from this study that the TNF2 allele contributes to the occurrence of eclampsia in our population.

    Original languageEnglish (US)
    Pages (from-to)204-209
    Number of pages6
    JournalGynecologic and Obstetric Investigation
    Volume57
    Issue number4
    DOIs
    StatePublished - 2004

    Keywords

    • Eclampsia
    • Pre-eclampsia
    • TNF-α -307 polymorphism

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Obstetrics and Gynecology

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