Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the framingham heart study offspring cohort

Renke Maas, Vanessa Xanthakis, Joseph F. Polak, Edzard Schwedhelm, Lisa M. Sullivan, Ralf Benndorf, Friedrich Schulze, Ramachandran S. Vasan, Philip A. Wolf, Rainer H. Böger, Sudha Seshadri

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE-: Higher plasma concentrations of the endogenous nitric oxides synthase inhibitor asymmetrical dimethylarginine (ADMA) are associated with increased risk of cardiovascular and cerebrovascular events and death, presumably by promoting endothelial dysfunction and subclinical atherosclerosis. We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT. METHODS-: We investigated the cross-sectional relations of plasma ADMA with CCA-IMT and ICA/bulb IMT in 2958 Framingham Heart Study participants (mean age, 58 years; 55% women). RESULTS-: In unadjusted analyses, ADMA was positively related to both CCA-IMT (β per SD increment, 0.012; P<0.001) and ICA/bulb IMT (β per SD increment, 0.059; P<0.001). In multivariable analyses (adjusting for age, sex, systolic blood pressure, antihypertensive treatment, smoking status, diabetes, BMI, total-to-HDL cholesterol ratio, log C-reactive protein, and serum creatinine), plasma ADMA was not associated with CCA-IMT (P=0.991), but remained significantly and positively related to ICA/bulb IMT (β per SD increment, 0.0246; P=0.002). CONCLUSIONS-: In our large community-based sample, we observed that higher plasma ADMA concentrations were associated with greater ICA/bulb IMT, but not with CCA-IMT. These data are consistent with the notion that ADMA promotes subclinical atherosclerosis in a site-specific manner, with a greater proatherogenic influence at known vulnerable sites in the arterial tree.

Original languageEnglish (US)
Pages (from-to)2715-2719
Number of pages5
JournalStroke
Volume40
Issue number8
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

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Tunica Intima
Carotid Arteries
Nitric Oxide Synthase
Common Carotid Artery
Cohort Studies
Atherosclerosis
Blood Pressure
dimethylarginine
C-Reactive Protein
HDL Cholesterol
Antihypertensive Agents
Creatinine
Smoking
Serum

Keywords

  • Carotid intimal medial thickness
  • Epidemiology
  • Risk factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the framingham heart study offspring cohort. / Maas, Renke; Xanthakis, Vanessa; Polak, Joseph F.; Schwedhelm, Edzard; Sullivan, Lisa M.; Benndorf, Ralf; Schulze, Friedrich; Vasan, Ramachandran S.; Wolf, Philip A.; Böger, Rainer H.; Seshadri, Sudha.

In: Stroke, Vol. 40, No. 8, 01.08.2009, p. 2715-2719.

Research output: Contribution to journalArticle

Maas, R, Xanthakis, V, Polak, JF, Schwedhelm, E, Sullivan, LM, Benndorf, R, Schulze, F, Vasan, RS, Wolf, PA, Böger, RH & Seshadri, S 2009, 'Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the framingham heart study offspring cohort', Stroke, vol. 40, no. 8, pp. 2715-2719. https://doi.org/10.1161/STROKEAHA.109.552539
Maas, Renke ; Xanthakis, Vanessa ; Polak, Joseph F. ; Schwedhelm, Edzard ; Sullivan, Lisa M. ; Benndorf, Ralf ; Schulze, Friedrich ; Vasan, Ramachandran S. ; Wolf, Philip A. ; Böger, Rainer H. ; Seshadri, Sudha. / Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the framingham heart study offspring cohort. In: Stroke. 2009 ; Vol. 40, No. 8. pp. 2715-2719.
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T1 - Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the framingham heart study offspring cohort

AU - Maas, Renke

AU - Xanthakis, Vanessa

AU - Polak, Joseph F.

AU - Schwedhelm, Edzard

AU - Sullivan, Lisa M.

AU - Benndorf, Ralf

AU - Schulze, Friedrich

AU - Vasan, Ramachandran S.

AU - Wolf, Philip A.

AU - Böger, Rainer H.

AU - Seshadri, Sudha

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N2 - BACKGROUND AND PURPOSE-: Higher plasma concentrations of the endogenous nitric oxides synthase inhibitor asymmetrical dimethylarginine (ADMA) are associated with increased risk of cardiovascular and cerebrovascular events and death, presumably by promoting endothelial dysfunction and subclinical atherosclerosis. We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT. METHODS-: We investigated the cross-sectional relations of plasma ADMA with CCA-IMT and ICA/bulb IMT in 2958 Framingham Heart Study participants (mean age, 58 years; 55% women). RESULTS-: In unadjusted analyses, ADMA was positively related to both CCA-IMT (β per SD increment, 0.012; P<0.001) and ICA/bulb IMT (β per SD increment, 0.059; P<0.001). In multivariable analyses (adjusting for age, sex, systolic blood pressure, antihypertensive treatment, smoking status, diabetes, BMI, total-to-HDL cholesterol ratio, log C-reactive protein, and serum creatinine), plasma ADMA was not associated with CCA-IMT (P=0.991), but remained significantly and positively related to ICA/bulb IMT (β per SD increment, 0.0246; P=0.002). CONCLUSIONS-: In our large community-based sample, we observed that higher plasma ADMA concentrations were associated with greater ICA/bulb IMT, but not with CCA-IMT. These data are consistent with the notion that ADMA promotes subclinical atherosclerosis in a site-specific manner, with a greater proatherogenic influence at known vulnerable sites in the arterial tree.

AB - BACKGROUND AND PURPOSE-: Higher plasma concentrations of the endogenous nitric oxides synthase inhibitor asymmetrical dimethylarginine (ADMA) are associated with increased risk of cardiovascular and cerebrovascular events and death, presumably by promoting endothelial dysfunction and subclinical atherosclerosis. We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT. METHODS-: We investigated the cross-sectional relations of plasma ADMA with CCA-IMT and ICA/bulb IMT in 2958 Framingham Heart Study participants (mean age, 58 years; 55% women). RESULTS-: In unadjusted analyses, ADMA was positively related to both CCA-IMT (β per SD increment, 0.012; P<0.001) and ICA/bulb IMT (β per SD increment, 0.059; P<0.001). In multivariable analyses (adjusting for age, sex, systolic blood pressure, antihypertensive treatment, smoking status, diabetes, BMI, total-to-HDL cholesterol ratio, log C-reactive protein, and serum creatinine), plasma ADMA was not associated with CCA-IMT (P=0.991), but remained significantly and positively related to ICA/bulb IMT (β per SD increment, 0.0246; P=0.002). CONCLUSIONS-: In our large community-based sample, we observed that higher plasma ADMA concentrations were associated with greater ICA/bulb IMT, but not with CCA-IMT. These data are consistent with the notion that ADMA promotes subclinical atherosclerosis in a site-specific manner, with a greater proatherogenic influence at known vulnerable sites in the arterial tree.

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