Association of the composite IL-1 genotype with peri-implantitis: A systematic review

G. Huynh-Ba, N. P. Lang, M. S. Tonetti, M. Zwahlen, G. E. Salvi

Research output: Contribution to journalArticle

29 Scopus citations


Objective: Cytokine gene polymorphisms may modulate the host response to the bacterial challenge and influence susceptibility to peri-implantitis. Objective: To systematically review the evidence of an association between the interleukin-1 (IL-1) composite genotype, i.e. presence of the allele 2 in the gene clusters IL-1A (-889) and in IL-1B (+3953), and peri-implantitis. Material and methods: An electronic search in the National Library of Medicine-computerized bibliographic database MEDLINE and a manual search were performed. The search was conducted for longitudinal clinical trials comparing progression of peri-implantitis in IL-1 genotype positive (carrying allele 2) with IL-1 genotype negative (not carrying allele 2) subjects. Selection of publications, extraction of data and validity assessment were made independently by two reviewers. Results: The search provided 44 titles of which two longitudinal publications were included. Conclusion: Based on the findings from this study, there is not enough evidence to support or refute an association between the IL-1 genotype status and peri-implantitis. Systematic genetic testing for the assessment of the risk of peri-implantitis cannot be recommended as a standard of care at this time.

Original languageEnglish (US)
Pages (from-to)1154-1162
Number of pages9
JournalClinical oral implants research
Issue number11
StatePublished - Nov 1 2008



  • Gene polymorphism
  • Implants
  • Interleukin-1
  • Peri-implantitis

ASJC Scopus subject areas

  • Oral Surgery

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