Association of TERT gene polymorphisms with clinical benign prostatic hyperplasia in a Chinese Han population of the Northwest region

Guangrui Fan, Kun Li, Yangyang Pang, Youli Zhao, Yan Tao, Huimin Gui, Hanzhang Wang, Robert Svatek, Ronald Rodriguez, Zhiping Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Background: To investigate the association between single nucleotide polymorphisms (rs10078761, rs12696304, rs2853669, rs16847897, rs2736100, rs10069690) of telomerase gene (TERT) and the risk clinical benign prostatic hyperplasia (BPH) in a Chinese Han population of the Northwest region. Methods: A total of 150 BPH patients and 150 healthy older males from the northwest Chinese Han population were included in this study. The sample size for this unmatched case-control study was estimated by the look-up table method. Meanwhile, the general information and disease data of patients were collected. Age was only collected in healthy control subjects for statistical correction. Genotypes were detected using a multiplex PCR + ligase detection reaction (LDR). Typing results and clinical data were statistically analyzed using multiple linear regression and logistic regression. Pearson correlation was used for Hardy-Weinberg equilibrium. Results: The included population is in Hardy-Weinberg equilibrium. There was no significant association between SNP and the risk of BPH by correlation analysis. However, 4 haplotypes (TCTGGT, TCTGTC, TGCCTC, and TGTGTC) were identified as risk factors of BPH by haplotype analysis. The SNP rs2853669 is an independent risk factor for smooth muscle type of hyperplasia. Besides, rs2736100, rs10078761, and rs10069690 which are in linkage disequilibrium are associated with the severity of BPH. Conclusions: Polymorphism of the TERT gene determines the different disease development and pathological manifestations of BPH in the Chinese Han population the Northwest region.

Original languageEnglish (US)
Pages (from-to)692-702
Number of pages11
JournalTranslational Andrology and Urology
Volume10
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • Benign prostatic hyperplasia (BPH)
  • Single nucleotide polymorphisms
  • Telomerase
  • Telomerase (TERT)

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology

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