Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study

Alison E. Fohner; Colleen M. Sitlani; Petra Buzkova; Margaret F. Doyle; Xiaojuan Liu; Joshua C. Bis; Annette Fitzpatrick; Susan R. Heckbert; Sally A. Huber; Lewis Kuller; William T. Longstreth; Matthew J. Feinstein; Matthew Freiberg; Nels C. Olson; Sudha Seshadri; Oscar Lopez; Michelle C. Odden; Russell P. Tracy; Bruce M. Psaty; Joseph A. Delaney; James S. Floyd

doi:10.3233/JAD-220091

Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study

Alison E. Fohner, Colleen M. Sitlani, Petra Buzkova, Margaret F. Doyle, Xiaojuan Liu, Joshua C. Bis, Annette Fitzpatrick, Susan R. Heckbert, Sally A. Huber, Lewis Kuller, William T. Longstreth, Matthew J. Feinstein, Matthew Freiberg, Nels C. Olson, Sudha Seshadri, Oscar Lopez, Michelle C. Odden, Russell P. Tracy, Bruce M. Psaty, Joseph A. DelaneyJames S. Floyd

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Inflammatory biomarkers in plasma are associated with dementia. Thus, we examined the association of 18 types of peripheral immune cells, measured as proportions of their immune cell type, with cross-sectional measures of cognitive function, change in cognitive function over seven years, prevalent dementia, and time to death from dementia in 1,928 participants of the Cardiovascular Health Study, with mean age 80 years and 62% female. We did not identify any associations after accounting for multiple comparisons, though we identified marginal associations of peripheral regulatory T cells with cognitive decline and dementia.

Original language	English (US)
Pages (from-to)	7-15
Number of pages	9
Journal	Journal of Alzheimer's Disease
Volume	88
Issue number	1
DOIs	https://doi.org/10.3233/JAD-220091
State	Published - 2022

Keywords

Alzheimer's disease
B cells
benton visual retention test
cognitive impairment
immune
natural killer cells

ASJC Scopus subject areas

Geriatrics and Gerontology
Psychiatry and Mental health
Clinical Psychology
General Neuroscience

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10.3233/JAD-220091

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Fohner, A. E., Sitlani, C. M., Buzkova, P., Doyle, M. F., Liu, X., Bis, J. C., Fitzpatrick, A., Heckbert, S. R., Huber, S. A., Kuller, L., Longstreth, W. T., Feinstein, M. J., Freiberg, M., Olson, N. C., Seshadri, S., Lopez, O., Odden, M. C., Tracy, R. P., Psaty, B. M., ... Floyd, J. S. (2022). Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study. Journal of Alzheimer's Disease, 88(1), 7-15. https://doi.org/10.3233/JAD-220091

Fohner, AE, Sitlani, CM, Buzkova, P, Doyle, MF, Liu, X, Bis, JC, Fitzpatrick, A, Heckbert, SR, Huber, SA, Kuller, L, Longstreth, WT, Feinstein, MJ, Freiberg, M, Olson, NC, Seshadri, S, Lopez, O, Odden, MC, Tracy, RP, Psaty, BM, Delaney, JA & Floyd, JS 2022, 'Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study', Journal of Alzheimer's Disease, vol. 88, no. 1, pp. 7-15. https://doi.org/10.3233/JAD-220091

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title = "Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study",

abstract = "Inflammatory biomarkers in plasma are associated with dementia. Thus, we examined the association of 18 types of peripheral immune cells, measured as proportions of their immune cell type, with cross-sectional measures of cognitive function, change in cognitive function over seven years, prevalent dementia, and time to death from dementia in 1,928 participants of the Cardiovascular Health Study, with mean age 80 years and 62% female. We did not identify any associations after accounting for multiple comparisons, though we identified marginal associations of peripheral regulatory T cells with cognitive decline and dementia.",

keywords = "Alzheimer's disease, B cells, benton visual retention test, cognitive impairment, immune, natural killer cells",

author = "Fohner, {Alison E.} and Sitlani, {Colleen M.} and Petra Buzkova and Doyle, {Margaret F.} and Xiaojuan Liu and Bis, {Joshua C.} and Annette Fitzpatrick and Heckbert, {Susan R.} and Huber, {Sally A.} and Lewis Kuller and Longstreth, {William T.} and Feinstein, {Matthew J.} and Matthew Freiberg and Olson, {Nels C.} and Sudha Seshadri and Oscar Lopez and Odden, {Michelle C.} and Tracy, {Russell P.} and Psaty, {Bruce M.} and Delaney, {Joseph A.} and Floyd, {James S.}",

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AU - Doyle, Margaret F.

AU - Liu, Xiaojuan

AU - Bis, Joshua C.

AU - Fitzpatrick, Annette

AU - Heckbert, Susan R.

AU - Huber, Sally A.

AU - Kuller, Lewis

AU - Longstreth, William T.

AU - Feinstein, Matthew J.

AU - Freiberg, Matthew

AU - Olson, Nels C.

AU - Seshadri, Sudha

AU - Lopez, Oscar

AU - Odden, Michelle C.

AU - Tracy, Russell P.

AU - Psaty, Bruce M.

AU - Delaney, Joseph A.

AU - Floyd, James S.

PY - 2022

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AB - Inflammatory biomarkers in plasma are associated with dementia. Thus, we examined the association of 18 types of peripheral immune cells, measured as proportions of their immune cell type, with cross-sectional measures of cognitive function, change in cognitive function over seven years, prevalent dementia, and time to death from dementia in 1,928 participants of the Cardiovascular Health Study, with mean age 80 years and 62% female. We did not identify any associations after accounting for multiple comparisons, though we identified marginal associations of peripheral regulatory T cells with cognitive decline and dementia.

KW - Alzheimer's disease

KW - B cells

KW - benton visual retention test

KW - cognitive impairment

KW - immune

KW - natural killer cells

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Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study

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