Association of Peripheral Lymphocyte Subsets with Cognitive Decline and Dementia: The Cardiovascular Health Study

Alison E. Fohner, Colleen M. Sitlani, Petra Buzkova, Margaret F. Doyle, Xiaojuan Liu, Joshua C. Bis, Annette Fitzpatrick, Susan R. Heckbert, Sally A. Huber, Lewis Kuller, William T. Longstreth, Matthew J. Feinstein, Matthew Freiberg, Nels C. Olson, Sudha Seshadri, Oscar Lopez, Michelle C. Odden, Russell P. Tracy, Bruce M. Psaty, Joseph A. DelaneyJames S. Floyd

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Inflammatory biomarkers in plasma are associated with dementia. Thus, we examined the association of 18 types of peripheral immune cells, measured as proportions of their immune cell type, with cross-sectional measures of cognitive function, change in cognitive function over seven years, prevalent dementia, and time to death from dementia in 1,928 participants of the Cardiovascular Health Study, with mean age 80 years and 62% female. We did not identify any associations after accounting for multiple comparisons, though we identified marginal associations of peripheral regulatory T cells with cognitive decline and dementia.

Original languageEnglish (US)
Pages (from-to)7-15
Number of pages9
JournalJournal of Alzheimer's Disease
Volume88
Issue number1
DOIs
StatePublished - 2022

Keywords

  • Alzheimer's disease
  • B cells
  • benton visual retention test
  • cognitive impairment
  • immune
  • natural killer cells

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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