TY - JOUR
T1 - Association of monocyte chemoattractant protein-1 with adipocyte number, insulin resistance and liver function markers
AU - Bose, Tanushree
AU - Alvarenga, Juan Carlos Lopez
AU - Tejero, M. Elizabeth
AU - Voruganti, V. Saroja
AU - Proffitt, J. Michael
AU - Freeland-Graves, Jeanne H.
AU - Cole, Shelley A.
AU - Comuzzie, Anthony G.
PY - 2009
Y1 - 2009
N2 - Background: Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine known to induce adipocyte dedifferentiation and insulin resistance. Inflammation, insulin resistance, and obesity have been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Methods: Fasting plasma from 43 baboons were assayed for MCP-1, insulin, glucose, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Adipocyte number and volume were measured via biopsies of omental adipose tissue. The homeostatic model assessment method (HOMA) was used to estimate systemic insulin resistance. Results: Sex and age adjusted correlations were significant for MCP-1 with adipocyte number (r = -0.42; P = 0.01), adipocyte volume (r = 0.38; P = 0.02), HOMA (r = 0.45; P = 0.004), ALT (r = 0.46; P = 0.03) and AST (r = 0.45; P = 0.03). Conclusions: These results suggest that MCP-1 is related with adipocyte dedifferentiation and systemic insulin resistance, thereby potentially contributing to the development of NAFLD.
AB - Background: Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine known to induce adipocyte dedifferentiation and insulin resistance. Inflammation, insulin resistance, and obesity have been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Methods: Fasting plasma from 43 baboons were assayed for MCP-1, insulin, glucose, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Adipocyte number and volume were measured via biopsies of omental adipose tissue. The homeostatic model assessment method (HOMA) was used to estimate systemic insulin resistance. Results: Sex and age adjusted correlations were significant for MCP-1 with adipocyte number (r = -0.42; P = 0.01), adipocyte volume (r = 0.38; P = 0.02), HOMA (r = 0.45; P = 0.004), ALT (r = 0.46; P = 0.03) and AST (r = 0.45; P = 0.03). Conclusions: These results suggest that MCP-1 is related with adipocyte dedifferentiation and systemic insulin resistance, thereby potentially contributing to the development of NAFLD.
KW - AST and ALT
KW - Adipocyte number
KW - Adipocyte volume
KW - Insulin resistance
KW - Liver function marker
KW - MCP-1
KW - NAFLD
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U2 - 10.1111/j.1600-0684.2009.00379.x
DO - 10.1111/j.1600-0684.2009.00379.x
M3 - Article
C2 - 19702660
AN - SCOPUS:74049131905
VL - 38
SP - 418
EP - 424
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - 6
ER -