Association of monocyte chemoattractant protein-1 with adipocyte number, insulin resistance and liver function markers

Tanushree Bose, Juan Carlos Lopez Alvarenga, M. Elizabeth Tejero, V. Saroja Voruganti, J. Michael Proffitt, Jeanne H. Freeland-Graves, Shelley A. Cole, Anthony G. Comuzzie

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations

    Abstract

    Background: Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine known to induce adipocyte dedifferentiation and insulin resistance. Inflammation, insulin resistance, and obesity have been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Methods: Fasting plasma from 43 baboons were assayed for MCP-1, insulin, glucose, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Adipocyte number and volume were measured via biopsies of omental adipose tissue. The homeostatic model assessment method (HOMA) was used to estimate systemic insulin resistance. Results: Sex and age adjusted correlations were significant for MCP-1 with adipocyte number (r = -0.42; P = 0.01), adipocyte volume (r = 0.38; P = 0.02), HOMA (r = 0.45; P = 0.004), ALT (r = 0.46; P = 0.03) and AST (r = 0.45; P = 0.03). Conclusions: These results suggest that MCP-1 is related with adipocyte dedifferentiation and systemic insulin resistance, thereby potentially contributing to the development of NAFLD.

    Original languageEnglish (US)
    Pages (from-to)418-424
    Number of pages7
    JournalJournal of medical primatology
    Volume38
    Issue number6
    DOIs
    StatePublished - 2009

    Keywords

    • AST and ALT
    • Adipocyte number
    • Adipocyte volume
    • Insulin resistance
    • Liver function marker
    • MCP-1
    • NAFLD

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)

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