Association of monocyte chemoattractant protein-1 with adipocyte number, insulin resistance and liver function markers

Tanushree Bose, Juan Carlos Lopez Alvarenga, M. Elizabeth Tejero, V. Saroja Voruganti, J. Michael Proffitt, Jeanne H. Freeland-Graves, Shelley A. Cole, Anthony G. Comuzzie

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Background: Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine known to induce adipocyte dedifferentiation and insulin resistance. Inflammation, insulin resistance, and obesity have been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Methods: Fasting plasma from 43 baboons were assayed for MCP-1, insulin, glucose, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Adipocyte number and volume were measured via biopsies of omental adipose tissue. The homeostatic model assessment method (HOMA) was used to estimate systemic insulin resistance. Results: Sex and age adjusted correlations were significant for MCP-1 with adipocyte number (r = -0.42; P = 0.01), adipocyte volume (r = 0.38; P = 0.02), HOMA (r = 0.45; P = 0.004), ALT (r = 0.46; P = 0.03) and AST (r = 0.45; P = 0.03). Conclusions: These results suggest that MCP-1 is related with adipocyte dedifferentiation and systemic insulin resistance, thereby potentially contributing to the development of NAFLD.

Original languageEnglish (US)
Pages (from-to)418-424
Number of pages7
JournalJournal of medical primatology
Volume38
Issue number6
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • AST and ALT
  • Adipocyte number
  • Adipocyte volume
  • Insulin resistance
  • Liver function marker
  • MCP-1
  • NAFLD

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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