Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population

Xiao Yun Cai, Xiao Feng Wang, Shi Lin Li, Ji Qian, De Gui Qian, Fei Chen, Ya Jun Yang, Zi Yu Yuan, Jun Xu, Yidong Bai, Shun Zhang Yu, Li Jin

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Background: Longevity is a multifactorial trait with a genetic contribution, and mitochondrial DNA (mtDNA) polymorphisms were found to be involved in the phenomenon of longevity. Methodology/Principal Findings: To explore the effects of mtDNA haplogroups on the prevalence of extreme longevity (EL), a population based case-control study was conducted in Rugao - a prefecture city in Jiangsu, China. Case subjects include 463 individuals aged ≥95 yr (EL group). Control subjects include 926 individuals aged 60-69 years (elderly group) and 463 individuals aged 40-49 years (middle-aged group) randomly recruited from Rugao. We observed significant reduction of M9 haplogroups in longevity subjects (0.2%) when compared with both elderly subjects (2.2%) and middleaged subjects (1.7%). Linear-by-linear association test revealed a significant decreasing trend of N9 frequency from middleaged subjects (8.6%), elderly subjects (7.2%) and longevity subjects (4.8%) (p = 0.018). In subsequent analysis stratified by gender, linear-by-linear association test revealed a significant increasing trend of D4 frequency from middle-aged subjects (15.8%), elderly subjects (16.4%) and longevity subjects (21.7%) in females (p = 0.025). Conversely, a significant decreasing trend of B4a frequency was observed from middle-aged subjects (4.2%), elderly subjects (3.8%) and longevity subjects (1.7%) in females (p = 0.045). Conclusions: Our observations support the association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.

Original languageEnglish (US)
Article numbere6423
JournalPloS one
Volume4
Issue number7
DOIs
StatePublished - Jul 29 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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