Association of IgA nephropathy with Clostridium difficile colitis.

W. J. Gaughan, M. H. Hassan, P. A. McCue, J. F. Burke, K. Sharma

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Immunoglobulin A (IgA) nephropathy, the most common cause of glomerulonephritis worldwide, is usually idiopathic in origin and renal limited. Secondary IgA nephropathy has been associated with systemic disease, including such gastrointestinal tract disturbances as celiac sprue and inflammatory bowel disease. We describe gross hematuria and reversible acute renal failure from IgA nephropathy in a patient with cephalosporin-induced Clostridium difficile colitis. In addition to mesangial IgA and C3 deposition, renal histological examination showed glomerular bleeding, intratubular red blood cell casts, and acute tubular necrosis. To the best of our knowledge, this is the first report of an association between IgA nephropathy and C difficile colitis.

Original languageEnglish (US)
Pages (from-to)e16
JournalAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
Issue number4
StatePublished - Oct 1999
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology


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