Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA

Paul N. Jensen; Tanweer Rashid; Jeffrey B. Ware; Yuhan Cui; Colleen M. Sitlani; Thomas R. Austin; W. T. Longstreth; Alain G. Bertoni; Elizabeth Mamourian; R. Nick Bryan; Ilya M. Nasrallah; Mohamad Habes; Susan R. Heckbert

doi:10.1002/alz.13346

Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA

Paul N. Jensen, Tanweer Rashid, Jeffrey B. Ware, Yuhan Cui, Colleen M. Sitlani, Thomas R. Austin, W. T. Longstreth, Alain G. Bertoni, Elizabeth Mamourian, R. Nick Bryan, Ilya M. Nasrallah, Mohamad Habes, Susan R. Heckbert

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

INTRODUCTION: Little is known about the epidemiology of brain microbleeds in racially/ethnically diverse populations. METHODS: In the Multi-Ethnic Study of Atherosclerosis, brain microbleeds were identified from 3T magnetic resonance imaging susceptibility-weighted imaging sequences using deep learning models followed by radiologist review. RESULTS: Among 1016 participants without prior stroke (25% Black, 15% Chinese, 19% Hispanic, 41% White, mean age 72), microbleed prevalence was 20% at age 60 to 64.9 and 45% at ≥85 years. Deep microbleeds were associated with older age, hypertension, higher body mass index, and atrial fibrillation, and lobar microbleeds with male sex and atrial fibrillation. Overall, microbleeds were associated with greater white matter hyperintensity volume and lower total white matter fractional anisotropy. DISCUSSION: Results suggest differing associations for lobar versus deep locations. Sensitive microbleed quantification will facilitate future longitudinal studies of their potential role as an early indicator of vascular pathology.

Original language	English (US)
Pages (from-to)	4139-4149
Number of pages	11
Journal	Alzheimer's and Dementia
Volume	19
Issue number	9
DOIs	https://doi.org/10.1002/alz.13346
State	Published - Sep 2023

Keywords

Multi-Ethnic Study of Atherosclerosis
atrial fibrillation
brain magnetic resonance imaging
brain microbleeds
cognition
deep learning
hypertension
race and ethnicity
small vessel disease
white matter fractional anisotropy
white matter hyperintensity

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1002/alz.13346

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title = "Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA",

abstract = "INTRODUCTION: Little is known about the epidemiology of brain microbleeds in racially/ethnically diverse populations. METHODS: In the Multi-Ethnic Study of Atherosclerosis, brain microbleeds were identified from 3T magnetic resonance imaging susceptibility-weighted imaging sequences using deep learning models followed by radiologist review. RESULTS: Among 1016 participants without prior stroke (25% Black, 15% Chinese, 19% Hispanic, 41% White, mean age 72), microbleed prevalence was 20% at age 60 to 64.9 and 45% at ≥85 years. Deep microbleeds were associated with older age, hypertension, higher body mass index, and atrial fibrillation, and lobar microbleeds with male sex and atrial fibrillation. Overall, microbleeds were associated with greater white matter hyperintensity volume and lower total white matter fractional anisotropy. DISCUSSION: Results suggest differing associations for lobar versus deep locations. Sensitive microbleed quantification will facilitate future longitudinal studies of their potential role as an early indicator of vascular pathology.",

keywords = "Multi-Ethnic Study of Atherosclerosis, atrial fibrillation, brain magnetic resonance imaging, brain microbleeds, cognition, deep learning, hypertension, race and ethnicity, small vessel disease, white matter fractional anisotropy, white matter hyperintensity",

author = "Jensen, {Paul N.} and Tanweer Rashid and Ware, {Jeffrey B.} and Yuhan Cui and Sitlani, {Colleen M.} and Austin, {Thomas R.} and Longstreth, {W. T.} and Bertoni, {Alain G.} and Elizabeth Mamourian and Bryan, {R. Nick} and Nasrallah, {Ilya M.} and Mohamad Habes and Heckbert, {Susan R.}",

note = "Publisher Copyright: {\textcopyright} 2023 the Alzheimer's Association.",

year = "2023",

month = sep,

doi = "10.1002/alz.13346",

language = "English (US)",

volume = "19",

pages = "4139--4149",

journal = "Alzheimer's and Dementia",

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publisher = "Elsevier Inc.",

number = "9",

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AU - Jensen, Paul N.

AU - Rashid, Tanweer

AU - Ware, Jeffrey B.

AU - Cui, Yuhan

AU - Sitlani, Colleen M.

AU - Austin, Thomas R.

AU - Longstreth, W. T.

AU - Bertoni, Alain G.

AU - Mamourian, Elizabeth

AU - Bryan, R. Nick

AU - Nasrallah, Ilya M.

AU - Habes, Mohamad

AU - Heckbert, Susan R.

PY - 2023/9

Y1 - 2023/9

N2 - INTRODUCTION: Little is known about the epidemiology of brain microbleeds in racially/ethnically diverse populations. METHODS: In the Multi-Ethnic Study of Atherosclerosis, brain microbleeds were identified from 3T magnetic resonance imaging susceptibility-weighted imaging sequences using deep learning models followed by radiologist review. RESULTS: Among 1016 participants without prior stroke (25% Black, 15% Chinese, 19% Hispanic, 41% White, mean age 72), microbleed prevalence was 20% at age 60 to 64.9 and 45% at ≥85 years. Deep microbleeds were associated with older age, hypertension, higher body mass index, and atrial fibrillation, and lobar microbleeds with male sex and atrial fibrillation. Overall, microbleeds were associated with greater white matter hyperintensity volume and lower total white matter fractional anisotropy. DISCUSSION: Results suggest differing associations for lobar versus deep locations. Sensitive microbleed quantification will facilitate future longitudinal studies of their potential role as an early indicator of vascular pathology.

AB - INTRODUCTION: Little is known about the epidemiology of brain microbleeds in racially/ethnically diverse populations. METHODS: In the Multi-Ethnic Study of Atherosclerosis, brain microbleeds were identified from 3T magnetic resonance imaging susceptibility-weighted imaging sequences using deep learning models followed by radiologist review. RESULTS: Among 1016 participants without prior stroke (25% Black, 15% Chinese, 19% Hispanic, 41% White, mean age 72), microbleed prevalence was 20% at age 60 to 64.9 and 45% at ≥85 years. Deep microbleeds were associated with older age, hypertension, higher body mass index, and atrial fibrillation, and lobar microbleeds with male sex and atrial fibrillation. Overall, microbleeds were associated with greater white matter hyperintensity volume and lower total white matter fractional anisotropy. DISCUSSION: Results suggest differing associations for lobar versus deep locations. Sensitive microbleed quantification will facilitate future longitudinal studies of their potential role as an early indicator of vascular pathology.

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KW - race and ethnicity

KW - small vessel disease

KW - white matter fractional anisotropy

KW - white matter hyperintensity

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Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA

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