Association of Baseline urodynamic measures of urethral function with clinical, demographic, and other urodynamic variables in women prior to undergoing midurethral sling surgery

the Urinary Incontinence Treatment Network (UITN)

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12 Scopus citations

Abstract

Aims To explore how baseline demographic, clinical, and urodynamic (UDS) variables correlate with measures of urethral function in women planning midurethral sling surgery. Methods Women with predominant stress urinary incontinence (SUI) as part of the trial of mid-urethral slings (TOMUS) were characterized preoperatively including: demographics, body mass index (BMI), responses to the Medical and Epidemiologic Social Aspects of Aging (MESA) and Urogenital Distress Inventory (UDI) questionnaires, pad weight (PW), incontinence duration, prior SUI surgery, prolapse, strength of pelvic contraction, Q-tip test, uroflow, cystometrogram, and detrusor pressures at maximum flow (Pdet at Qmax). Multivariate regression analysis and modeling confirmed variables with significant correlations with maximal urethral closure pressure (MUCP), functional urethral length (FUL), and Valsalva leak point pressure (VLPP). Results Five-hundred thirty-nine women were included in the analysis. In multivariable analyses, PW (P=0.045) and age (P<0.0001) were negatively correlated with MUCP (as PW and age increased, MUCP decreased); BMI (P=0.02) and Pdet at Qmax (P<0.0001) were positively correlated with MUCP (as BMI and Pdet at Qmax increased, MUCP increased). Age (P=0.002) was negatively correlated with FUL; Qtip delta (P=0.006), pelvic organ prolapse quantification examination (POPQ) stage (P=0.002) and strength of pelvic contraction (P=0.03) were positively correlated with FUL. Duration of incontinence (P=0.01) was negatively correlated with VLPP; Qtip delta (P=0.02), BMI (P=0.0005) and Pdet at Qmax (P=0.0005) were positively correlated with VLPP. Conclusions Age, BMI, Qtip delta, and Pdet at Qmax were variables that correlated with two or more measures of urethral function. These correlations may help direct future research in female urethral function.

Original languageEnglish (US)
Pages (from-to)496-501
Number of pages6
JournalNeurourology and Urodynamics
Volume31
Issue number4
DOIs
StatePublished - Apr 1 2012

Keywords

  • Valsalva leak point pressure
  • clinicodemographic variables
  • stress urinary incontinence
  • surgery
  • urethral pressure profile

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology

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