TY - JOUR
T1 - Association of ADAM10 and CAMK2A polymorphisms with conduct disorder
T2 - Evidence from family-based studies
AU - Jian, Xue Qiu
AU - Wang, Ke Sheng
AU - Wu, Tie Jian
AU - Hillhouse, Joel J.
AU - Mullersman, Jerald E.
N1 - Funding Information:
Acknowledgements The Collaborative Study on the Genetics of Alcoholism (COGA) (H. Begleiter, SUNY HSCB, Principal Investigator: T. Reich, Washington University, Co-Principal Investigator) includes nine centers where data collection, analysis, and/or storage take place. This national collaborative study is supported by NIH grant U10AA08403 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The National Institute of General Medical Sciences has provided continuous funding for the Genetic Analysis Workshops (GAW) since 1982, through grant R01 GM31575 to Jean MacCluer (Southwest Foundation for Biomedical Research). The GAW14 data was kindly provided by Jean MacCluer. We acknowledge the contributions of the COGA, supported by NIH Grants U10AA08401 and U10AA08403 (NIAAA) and the contributions of all scientists who have provided genotyping data to the Wave I and/or Wave II—Genetic Analysis Data. We were granted access to the COGA data by NIAAA. The dataset for replication study was obtained from the GAIN Database found at http://www.ncbi.nlm.nih. gov/projects/gap/ through the dbGAP accession number phs000016. v1.p1. The International Multi-Center ADHD Genetics Project (IMAGE) project is a multi-site, international effort supported by NIH grants R01MH081803 and R01MH62873 to Stephen V. Faraone. The genotyping of samples was provided through the Genetic Association Information Network (GAIN). Samples and associated phenotype data for The International Multi-Center ADHD Genetics Project (IMAGE) project were provided by Dr Stephen V. Faraone. We thank all the families who kindly participated in this research. This study is part of project “Genetic analysis of alcohol dependence and alcohol-related phenotypes” approved by IRB, East Tennessee State University.
PY - 2011/8
Y1 - 2011/8
N2 - Twin and family studies have shown that genetic factors play a role in the development of conduct disorder (CD). The purpose of this study was to identify genetic variants associated with CD using a family-based association study. We used 4,720 single nucleotide polymorphisms (SNPs) from the Illumina Panel and 11,120 SNPs from the Affymetrix 10K GeneChips genotyped in 155 Caucasian nuclear families from Genetic Analysis Workshop (GAW) 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). 20 SNPs had suggestive associations with CD (p∈<∈10-3), nine of which were located in known genes, including ADAM10 (rs383902, p=0.00036) and CAMK2A (rs2053053, p=0.00098). Our results were verified using the International Multi-Center ADHD Genetics Project (IMAGE) dataset. In conclusion, we identified several loci associated with CD. Especially, the two genes (ADAM10 and CAMK2A) have been reported to be associated with Alzheimer's disease, bipolar disorder and depression. These findings may serve as a resource for replication in other populations.
AB - Twin and family studies have shown that genetic factors play a role in the development of conduct disorder (CD). The purpose of this study was to identify genetic variants associated with CD using a family-based association study. We used 4,720 single nucleotide polymorphisms (SNPs) from the Illumina Panel and 11,120 SNPs from the Affymetrix 10K GeneChips genotyped in 155 Caucasian nuclear families from Genetic Analysis Workshop (GAW) 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). 20 SNPs had suggestive associations with CD (p∈<∈10-3), nine of which were located in known genes, including ADAM10 (rs383902, p=0.00036) and CAMK2A (rs2053053, p=0.00098). Our results were verified using the International Multi-Center ADHD Genetics Project (IMAGE) dataset. In conclusion, we identified several loci associated with CD. Especially, the two genes (ADAM10 and CAMK2A) have been reported to be associated with Alzheimer's disease, bipolar disorder and depression. These findings may serve as a resource for replication in other populations.
KW - ADAM10
KW - CAMK2A
KW - Conduct disorder
KW - Family-based design
KW - Single nucleotide polymorphisms
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U2 - 10.1007/s10802-011-9524-4
DO - 10.1007/s10802-011-9524-4
M3 - Article
C2 - 21611732
AN - SCOPUS:79959827570
VL - 39
SP - 773
EP - 782
JO - Journal of Abnormal Child Psychology
JF - Journal of Abnormal Child Psychology
SN - 0091-0627
IS - 6
ER -