Association of a vitamin D receptor polymorphism with sporadic breast cancer development

Joanne E. Curran, Tanya Vaughan, Rod A. Lea, Stephen R. Weinstein, Nigel A. Morrison, Lyn R. Griffiths

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    Abstract

    Breast cancer is the leading cause of cancer death among Australian women and its incidence is annually increasing. Genetic factors are involved in the complex etiology of breast cancer. The seco-steroid hormone, 1.25 dihydroxy vitamin D3 can influence breast cancer cell growth in vitro. A number of studies have reported correlations between vitamin D receptor (VDR) gene polymorphisms and several diseases including prostate cancer and osteoporosis. In breast cancer, low vitamin D levels in serum are correlated with disease progression and bone metastases, a situation also noted in prostate cancer and suggesting the involvement of the VDR. In our study, 2 restriction fragment length polymorphisms (RFLP) in the 3' region (detected by ApaI and TaqI) and an initiation codon variant in the 5' end of the VDR gene (detected by FokI) were tested for association with breast cancer risk in 135 females with sporadic breast cancer and 110 cancer-free female controls. Allele frequencies of the 3' ApaI polymorphism showed a significant association (p = 0.016; OR = 1.56, 95% CI = 1.09-2.24) while the TaqI RFLP showed a similar trend (p = 0.053; OR = 1.45, 95% CI = 1.00-2.00). Allele frequencies of the FokI polymorphism were not significantly different (p = 0.97; OR = 0.99, 95% CI = 0.69-1.43) in the study population. Our results suggest that specific alleles of the VDR gene located near the 3' region may identify an increased risk for breast cancer and justify further investigation of the role of VDR in breast cancer.

    Original languageEnglish (US)
    Pages (from-to)723-726
    Number of pages4
    JournalInternational Journal of Cancer
    Volume83
    Issue number6
    DOIs
    Publication statusPublished - Dec 17 1999

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    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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