TY - JOUR
T1 - Association between waist circumference and gray matter volume in 2344 individuals from two adult community-based samples
AU - Janowitz, Deborah
AU - Wittfeld, Katharina
AU - Terock, Jan
AU - Freyberger, Harald Jürgen
AU - Hegenscheid, Katrin
AU - Völzke, Henry
AU - Habes, Mohamad
AU - Hosten, Norbert
AU - Friedrich, Nele
AU - Nauck, Matthias
AU - Domanska, Grazyna
AU - Grabe, Hans Jörgen
N1 - Funding Information:
The Study of Health in Pomerania (SHIP) is supported by the German Federal Ministry of Education and Research (grants 01ZZ9603 , 01ZZ0103 and 01ZZ0403 ) and the German Research Foundation (DFG; GR 1912/5-1 ). MRI scans were supported by the Federal Ministry of Education and Research (grant 03ZIK012 ) and a joint grant from Siemens Healthcare, Erlangen, Germany , and the Federal State of Mecklenburg—West Pomerania .
Funding Information:
This cohort is part of the Community Medicine Research net (CMR) of the University of Greifswald, which is funded by the German Federal Ministry of Education and Research and the German Ministry of Cultural Affairs , as well as by the Social Ministry of the Federal State of Mecklenburg—West Pomerania . CMR encompasses several research projects that share data from the population-based Study of Health in Pomerania (SHIP; see URLs). The work is also supported by the German Research Foundation (DFG; GR 1912/5-1 ) and the Greifswald Approach to Individualized Medicine (GANI_MED) network funded by the Federal Ministry of Education and Research (grant 03IS2061A ). We thank all staff members and participants of the SHIP studies. We are especially grateful to Alexander Teumer PhD (Institute of Community Medicine, University Medicine Greifswald, Germany) for his critical comments and help to improve the paper.
PY - 2015/11/5
Y1 - 2015/11/5
N2 - We analyzed the putative association between abdominal obesity (measured in waist circumference) and gray matter volume (Study of Health in Pomerania: SHIP-2, N. =. 758) adjusted for age and gender by applying volumetric analysis and voxel-based morphometry (VBM) with VBM8 to brain magnetic resonance (MR) imaging.We sought replication in a second, independent population sample (SHIP-TREND, N = 1586). In a combined analysis (SHIP-2 and SHIP-TREND) we investigated the impact of hypertension, type II diabetes and blood lipids on the association between waist circumference and gray matter. Volumetric analysis revealed a significant inverse association between waist circumference and gray matter volume. VBM in SHIP-2 indicated distinct inverse associations in the following structures for both hemispheres: frontal lobe, temporal lobes, pre- and postcentral gyrus, supplementary motor area, supramarginal gyrus, insula, cingulate gyrus, caudate nucleus, olfactory sulcus, para-/hippocampus, gyrus rectus, amygdala, globus pallidus, putamen, cerebellum, fusiform and lingual gyrus, (pre-) cuneus and thalamus. These areas were replicated in SHIP-TREND. More than 76% of the voxels with significant gray matter volume reduction in SHIP-2 were also distinct in TREND. These brain areas are involved in cognition, attention to interoceptive signals as satiety or reward and control food intake. Due to our cross-sectional design we cannot clarify the causal direction of the association. However, previous studies described an association between subjects with higher waist circumference and future cognitive decline suggesting a progressive brain alteration in obese subjects. Pathomechanisms may involve chronic inflammation, increased oxidative stress or cellular autophagy associated with obesity.
AB - We analyzed the putative association between abdominal obesity (measured in waist circumference) and gray matter volume (Study of Health in Pomerania: SHIP-2, N. =. 758) adjusted for age and gender by applying volumetric analysis and voxel-based morphometry (VBM) with VBM8 to brain magnetic resonance (MR) imaging.We sought replication in a second, independent population sample (SHIP-TREND, N = 1586). In a combined analysis (SHIP-2 and SHIP-TREND) we investigated the impact of hypertension, type II diabetes and blood lipids on the association between waist circumference and gray matter. Volumetric analysis revealed a significant inverse association between waist circumference and gray matter volume. VBM in SHIP-2 indicated distinct inverse associations in the following structures for both hemispheres: frontal lobe, temporal lobes, pre- and postcentral gyrus, supplementary motor area, supramarginal gyrus, insula, cingulate gyrus, caudate nucleus, olfactory sulcus, para-/hippocampus, gyrus rectus, amygdala, globus pallidus, putamen, cerebellum, fusiform and lingual gyrus, (pre-) cuneus and thalamus. These areas were replicated in SHIP-TREND. More than 76% of the voxels with significant gray matter volume reduction in SHIP-2 were also distinct in TREND. These brain areas are involved in cognition, attention to interoceptive signals as satiety or reward and control food intake. Due to our cross-sectional design we cannot clarify the causal direction of the association. However, previous studies described an association between subjects with higher waist circumference and future cognitive decline suggesting a progressive brain alteration in obese subjects. Pathomechanisms may involve chronic inflammation, increased oxidative stress or cellular autophagy associated with obesity.
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U2 - 10.1016/j.neuroimage.2015.07.086
DO - 10.1016/j.neuroimage.2015.07.086
M3 - Article
C2 - 26256530
AN - SCOPUS:84939625730
VL - 122
SP - 149
EP - 157
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
ER -