TY - JOUR
T1 - Association between serum neuron-specific enolase, age, overweight, and structural MRI patterns in 901 subjects
AU - Hoffmann, Johanna
AU - Janowitz, Deborah
AU - Van Der Auwera, Sandra
AU - Wittfeld, Katharina
AU - Nauck, Matthias
AU - Friedrich, Nele
AU - Habes, Mohamad
AU - Davatzikos, Christos
AU - Terock, Jan
AU - Bahls, Martin
AU - Goltz, Annemarie
AU - Kuhla, Angela
AU - Völzke, Henry
AU - Jörgen Grabe, Hans
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Serum neuron-specific enolase (sNSE) is considered a marker for neuronal damage, related to gray matter structures. Previous studies indicated its potential as marker for structural and functional damage in conditions with adverse effects to the brain like obesity and dementia. In the present study, we investigated the putative association between sNSE levels, body mass index (BMI), total gray matter volume (GMV), and magnetic resonance imaging-based indices of aging as well as Alzheimer's disease (AD)-like patterns. Subjects/Methods: sNSE was determined in 901 subjects (499 women, 22-81 years, BMI 18-48 kg/m2), participating in a population-based study (SHIP-TREND). We report age-specific patterns of sNSE levels between males and females. Females showed augmenting, males decreasing sNSE levels associated with age (males: p = 0.1052, females: p = 0.0363). sNSE levels and BMI were non-linearly associated, showing a parabolic association and decreasing sNSE levels at BMI values >25 (p = 0.0056). In contrast to our hypotheses, sNSE levels were not associated with total GMV, aging, or AD-like patterns. Pathomechanisms discussed are: sex-specific hormonal differences, neuronal damage/differentiation, or impaired cerebral glucose metabolism. We assume a sex-dependence of age-related effects to the brain. Further, we propose in accordance to previous studies an actual neuronal damage in the early stages of obesity. However, with progression of overweight, we assume more profound effects of excess body fat to the brain.
AB - Serum neuron-specific enolase (sNSE) is considered a marker for neuronal damage, related to gray matter structures. Previous studies indicated its potential as marker for structural and functional damage in conditions with adverse effects to the brain like obesity and dementia. In the present study, we investigated the putative association between sNSE levels, body mass index (BMI), total gray matter volume (GMV), and magnetic resonance imaging-based indices of aging as well as Alzheimer's disease (AD)-like patterns. Subjects/Methods: sNSE was determined in 901 subjects (499 women, 22-81 years, BMI 18-48 kg/m2), participating in a population-based study (SHIP-TREND). We report age-specific patterns of sNSE levels between males and females. Females showed augmenting, males decreasing sNSE levels associated with age (males: p = 0.1052, females: p = 0.0363). sNSE levels and BMI were non-linearly associated, showing a parabolic association and decreasing sNSE levels at BMI values >25 (p = 0.0056). In contrast to our hypotheses, sNSE levels were not associated with total GMV, aging, or AD-like patterns. Pathomechanisms discussed are: sex-specific hormonal differences, neuronal damage/differentiation, or impaired cerebral glucose metabolism. We assume a sex-dependence of age-related effects to the brain. Further, we propose in accordance to previous studies an actual neuronal damage in the early stages of obesity. However, with progression of overweight, we assume more profound effects of excess body fat to the brain.
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U2 - 10.1038/s41398-017-0035-0
DO - 10.1038/s41398-017-0035-0
M3 - Article
C2 - 29217819
AN - SCOPUS:85038087589
SN - 2158-3188
VL - 7
JO - Translational psychiatry
JF - Translational psychiatry
IS - 12
M1 - 1272
ER -