Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB

Lawrence D. Kerr; Lynn J. Ransone; Penny Wamsley; Mark J. Schmitt; Thomas G. Boyer; Qiang Zhou; Arnold J. Berk; Inder M. Verma

doi:10.1038/365412a0

Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB

Lawrence D. Kerr
, Lynn J. Ransone
, Penny Wamsley
, Mark J. Schmitt
, Thomas G. Boyer
, Qiang Zhou
, Arnold J. Berk
, Inder M. Verma

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

Abstract

The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the κB site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between κB enhancer binding proteins and basal transcription factors which leads to enhanced transcription.

Original language	English (US)
Pages (from-to)	412-419
Number of pages	8
Journal	Nature
Volume	365
Issue number	6445
DOIs	https://doi.org/10.1038/365412a0
State	Published - 1993
Externally published	Yes

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@article{5a69da43d9fb4a1a85ffdd5de5697563,

title = "Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB",

abstract = "The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the κB site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between κB enhancer binding proteins and basal transcription factors which leads to enhanced transcription.",

author = "Kerr, \{Lawrence D.\} and Ransone, \{Lynn J.\} and Penny Wamsley and Schmitt, \{Mark J.\} and Boyer, \{Thomas G.\} and Qiang Zhou and Berk, \{Arnold J.\} and Verma, \{Inder M.\}",

year = "1993",

doi = "10.1038/365412a0",

language = "English (US)",

volume = "365",

pages = "412--419",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "6445",

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TY - JOUR

T1 - Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB

AU - Kerr, Lawrence D.

AU - Ransone, Lynn J.

AU - Wamsley, Penny

AU - Schmitt, Mark J.

AU - Boyer, Thomas G.

AU - Zhou, Qiang

AU - Berk, Arnold J.

AU - Verma, Inder M.

PY - 1993

Y1 - 1993

N2 - The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the κB site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between κB enhancer binding proteins and basal transcription factors which leads to enhanced transcription.

AB - The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the κB site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between κB enhancer binding proteins and basal transcription factors which leads to enhanced transcription.

UR - https://www.scopus.com/pages/publications/0027454228

UR - https://www.scopus.com/pages/publications/0027454228#tab=citedBy

U2 - 10.1038/365412a0

DO - 10.1038/365412a0

M3 - Article

C2 - 8413585

AN - SCOPUS:0027454228

SN - 0028-0836

VL - 365

SP - 412

EP - 419

JO - Nature

JF - Nature

IS - 6445

ER -

Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB

Abstract

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