Abstract
The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the κB site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between κB enhancer binding proteins and basal transcription factors which leads to enhanced transcription.
Original language | English (US) |
---|---|
Pages (from-to) | 412-419 |
Number of pages | 8 |
Journal | Nature |
Volume | 365 |
Issue number | 6445 |
DOIs | |
State | Published - Jan 1 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- General