Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB

Lawrence D. Kerr, Lynn J. Ransone, Penny Wamsley, Mark J. Schmitt, Thomas G. Boyer, Qiang Zhou, Arnold J. Berk, Inder M. Verma

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the κB site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between κB enhancer binding proteins and basal transcription factors which leads to enhanced transcription.

Original languageEnglish (US)
Pages (from-to)412-419
Number of pages8
JournalNature
Volume365
Issue number6445
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • General

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