TY - JOUR
T1 - Association between obesity-related biomarkers and cognitive and motor development in infants
AU - Camargos, Ana Cristina R.
AU - Mendonça, Vanessa A.
AU - Oliveira, Katherine S.C.
AU - de Andrade, Camila Alves
AU - Leite, Hércules Ribeiro
AU - da Fonseca, Sueli Ferreira
AU - Vieira, Erica Leandro Marciano
AU - Teixeira Júnior, Antônio Lúcio
AU - Lacerda, Ana Cristina Rodrigues
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/5/15
Y1 - 2017/5/15
N2 - Background This study aimed to verify the association between obesity-related biomarkers and cognitive and motor development in infants between 6 and 24 months of age. Methods A cross-sectional study was conducted with 50 infants and plasma levels of leptin, adiponectin, resistin, soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and sTNFR2), chemokines, brain-derived neurotrophic factor (BDNF), serum cortisol and redox status were measured. The Bayley-III test was utilized to evaluate cognitive and motor development, and multiple linear stepwise regression models were performed to verify the association between selected biomarkers and cognitive and motor development. Results A significant association was found among plasma leptin and sTNFR1 levels with cognitive composite scores, and these two independents variables together explained 37% of the variability of cognitive composite scores (p = 0.001). Only plasma sTNFR1 levels were associated and explained 24% of the variability of motor composite scores (p = 0.003). Conclusions Plasma levels of sTNFR1 were associated with the increase in cognitive and motor development scores in infants between 6 and 24 months of age through a mechanism not directly related to excess body weight. Moreover, increase in plasma levels of leptin reduced the cognitive development in this age range.
AB - Background This study aimed to verify the association between obesity-related biomarkers and cognitive and motor development in infants between 6 and 24 months of age. Methods A cross-sectional study was conducted with 50 infants and plasma levels of leptin, adiponectin, resistin, soluble tumor necrosis factor receptors 1 and 2 (sTNFR1 and sTNFR2), chemokines, brain-derived neurotrophic factor (BDNF), serum cortisol and redox status were measured. The Bayley-III test was utilized to evaluate cognitive and motor development, and multiple linear stepwise regression models were performed to verify the association between selected biomarkers and cognitive and motor development. Results A significant association was found among plasma leptin and sTNFR1 levels with cognitive composite scores, and these two independents variables together explained 37% of the variability of cognitive composite scores (p = 0.001). Only plasma sTNFR1 levels were associated and explained 24% of the variability of motor composite scores (p = 0.003). Conclusions Plasma levels of sTNFR1 were associated with the increase in cognitive and motor development scores in infants between 6 and 24 months of age through a mechanism not directly related to excess body weight. Moreover, increase in plasma levels of leptin reduced the cognitive development in this age range.
KW - Adipokines
KW - Biomarkers
KW - Child development
KW - Infant obesity
UR - http://www.scopus.com/inward/record.url?scp=85014093512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014093512&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2017.02.030
DO - 10.1016/j.bbr.2017.02.030
M3 - Article
C2 - 28238825
AN - SCOPUS:85014093512
SN - 0166-4328
VL - 325
SP - 12
EP - 16
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -