Association between NIDDM, RH blood group, and haptoglobin phenotype. Results from the San Antonio Heart Study

M. P. Stern, R. E. Ferrell, M. Rosenthal, S. M. Haffner, H. P. Hazuda

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

We examined seven red cell antigen and 10 polymorphic protein phenotypes in 1237 Mexican Americans randomly selected from three San Antonio neighborhoods. Statistically significant associations were found between non-insulin-dependent diabetes mellitus (NIDDM) and RH blood type (X2 = 32.87, df = 10, P = 0.0003) and haptoglobin phenotype (X2 = 9.15, df = 2, P = 0.010). The haptoglobin association showed a dose effect with a single dose of the haptoglobin-1 allele associated with an approximately 50% increase and a double dose of the haptoglobin-1 allele associated with an approximately 100% increase in NIDDM prevalence. Multivariate analysis indicated statistically significant associations between NIDDM and age, sex, adiposity, and neighborhood of resistance. However, even after taking these potential confounding variables into account, there was still a signficant, independent association between NIDDM and haptoglobin phenotype. The results suggest that the haptoglobin gene may be in linkage disequilibrium with a major susceptibility gene for NIDDM.

Original languageEnglish (US)
Pages (from-to)387-391
Number of pages5
JournalDiabetes
Volume35
Issue number4
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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