Association between NIDDM, RH blood group, and haptoglobin phenotype. Results from the San Antonio Heart Study

M. P. Stern, R. E. Ferrell, M. Rosenthal, S. M. Haffner, Helen P Hazuda

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We examined seven red cell antigen and 10 polymorphic protein phenotypes in 1237 Mexican Americans randomly selected from three San Antonio neighborhoods. Statistically significant associations were found between non-insulin-dependent diabetes mellitus (NIDDM) and RH blood type (X2 = 32.87, df = 10, P = 0.0003) and haptoglobin phenotype (X2 = 9.15, df = 2, P = 0.010). The haptoglobin association showed a dose effect with a single dose of the haptoglobin-1 allele associated with an approximately 50% increase and a double dose of the haptoglobin-1 allele associated with an approximately 100% increase in NIDDM prevalence. Multivariate analysis indicated statistically significant associations between NIDDM and age, sex, adiposity, and neighborhood of resistance. However, even after taking these potential confounding variables into account, there was still a signficant, independent association between NIDDM and haptoglobin phenotype. The results suggest that the haptoglobin gene may be in linkage disequilibrium with a major susceptibility gene for NIDDM.

Original languageEnglish (US)
Pages (from-to)387-391
Number of pages5
JournalDiabetes
Volume35
Issue number4
StatePublished - 1986
Externally publishedYes

Fingerprint

Haptoglobins
Blood Group Antigens
Type 2 Diabetes Mellitus
Phenotype
Alleles
Confounding Factors (Epidemiology)
Linkage Disequilibrium
Adiposity
Genes
Multivariate Analysis
Antigens
Proteins

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Stern, M. P., Ferrell, R. E., Rosenthal, M., Haffner, S. M., & Hazuda, H. P. (1986). Association between NIDDM, RH blood group, and haptoglobin phenotype. Results from the San Antonio Heart Study. Diabetes, 35(4), 387-391.

Association between NIDDM, RH blood group, and haptoglobin phenotype. Results from the San Antonio Heart Study. / Stern, M. P.; Ferrell, R. E.; Rosenthal, M.; Haffner, S. M.; Hazuda, Helen P.

In: Diabetes, Vol. 35, No. 4, 1986, p. 387-391.

Research output: Contribution to journalArticle

Stern, MP, Ferrell, RE, Rosenthal, M, Haffner, SM & Hazuda, HP 1986, 'Association between NIDDM, RH blood group, and haptoglobin phenotype. Results from the San Antonio Heart Study', Diabetes, vol. 35, no. 4, pp. 387-391.
Stern MP, Ferrell RE, Rosenthal M, Haffner SM, Hazuda HP. Association between NIDDM, RH blood group, and haptoglobin phenotype. Results from the San Antonio Heart Study. Diabetes. 1986;35(4):387-391.
Stern, M. P. ; Ferrell, R. E. ; Rosenthal, M. ; Haffner, S. M. ; Hazuda, Helen P. / Association between NIDDM, RH blood group, and haptoglobin phenotype. Results from the San Antonio Heart Study. In: Diabetes. 1986 ; Vol. 35, No. 4. pp. 387-391.
@article{69784919ca9545e097cbf0e6f0f4fb12,
title = "Association between NIDDM, RH blood group, and haptoglobin phenotype. Results from the San Antonio Heart Study",
abstract = "We examined seven red cell antigen and 10 polymorphic protein phenotypes in 1237 Mexican Americans randomly selected from three San Antonio neighborhoods. Statistically significant associations were found between non-insulin-dependent diabetes mellitus (NIDDM) and RH blood type (X2 = 32.87, df = 10, P = 0.0003) and haptoglobin phenotype (X2 = 9.15, df = 2, P = 0.010). The haptoglobin association showed a dose effect with a single dose of the haptoglobin-1 allele associated with an approximately 50{\%} increase and a double dose of the haptoglobin-1 allele associated with an approximately 100{\%} increase in NIDDM prevalence. Multivariate analysis indicated statistically significant associations between NIDDM and age, sex, adiposity, and neighborhood of resistance. However, even after taking these potential confounding variables into account, there was still a signficant, independent association between NIDDM and haptoglobin phenotype. The results suggest that the haptoglobin gene may be in linkage disequilibrium with a major susceptibility gene for NIDDM.",
author = "Stern, {M. P.} and Ferrell, {R. E.} and M. Rosenthal and Haffner, {S. M.} and Hazuda, {Helen P}",
year = "1986",
language = "English (US)",
volume = "35",
pages = "387--391",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "4",

}

TY - JOUR

T1 - Association between NIDDM, RH blood group, and haptoglobin phenotype. Results from the San Antonio Heart Study

AU - Stern, M. P.

AU - Ferrell, R. E.

AU - Rosenthal, M.

AU - Haffner, S. M.

AU - Hazuda, Helen P

PY - 1986

Y1 - 1986

N2 - We examined seven red cell antigen and 10 polymorphic protein phenotypes in 1237 Mexican Americans randomly selected from three San Antonio neighborhoods. Statistically significant associations were found between non-insulin-dependent diabetes mellitus (NIDDM) and RH blood type (X2 = 32.87, df = 10, P = 0.0003) and haptoglobin phenotype (X2 = 9.15, df = 2, P = 0.010). The haptoglobin association showed a dose effect with a single dose of the haptoglobin-1 allele associated with an approximately 50% increase and a double dose of the haptoglobin-1 allele associated with an approximately 100% increase in NIDDM prevalence. Multivariate analysis indicated statistically significant associations between NIDDM and age, sex, adiposity, and neighborhood of resistance. However, even after taking these potential confounding variables into account, there was still a signficant, independent association between NIDDM and haptoglobin phenotype. The results suggest that the haptoglobin gene may be in linkage disequilibrium with a major susceptibility gene for NIDDM.

AB - We examined seven red cell antigen and 10 polymorphic protein phenotypes in 1237 Mexican Americans randomly selected from three San Antonio neighborhoods. Statistically significant associations were found between non-insulin-dependent diabetes mellitus (NIDDM) and RH blood type (X2 = 32.87, df = 10, P = 0.0003) and haptoglobin phenotype (X2 = 9.15, df = 2, P = 0.010). The haptoglobin association showed a dose effect with a single dose of the haptoglobin-1 allele associated with an approximately 50% increase and a double dose of the haptoglobin-1 allele associated with an approximately 100% increase in NIDDM prevalence. Multivariate analysis indicated statistically significant associations between NIDDM and age, sex, adiposity, and neighborhood of resistance. However, even after taking these potential confounding variables into account, there was still a signficant, independent association between NIDDM and haptoglobin phenotype. The results suggest that the haptoglobin gene may be in linkage disequilibrium with a major susceptibility gene for NIDDM.

UR - http://www.scopus.com/inward/record.url?scp=0022481806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022481806&partnerID=8YFLogxK

M3 - Article

C2 - 3082699

AN - SCOPUS:0022481806

VL - 35

SP - 387

EP - 391

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 4

ER -