TY - JOUR
T1 - Association between inflammatory biomarkers in plasma, radiological severity, and duration of exposure in patients with silicosis
AU - Braz, Nayara Felicidade Tomaz
AU - Carneiro, Ana Paula Scalia
AU - Amorim, Mateus Ramos
AU - De Oliveira Ferreira, Fernanda
AU - Lacerda, Ana Cristina Rodrigues
AU - Silva De Miranda, Aline
AU - Teixeira, Mauro Martins
AU - Teixeira, Antonio Lucio
AU - Mendonça, Vanessa Amaral
PY - 2014/5
Y1 - 2014/5
N2 - OBJECTIVE:: To evaluate the plasma levels of CCL2, CCL3, CCL11, CCL24, tumor necrosis factor alpha, sTNFR1, and sTNFR2 in subjects exposed to silica (SES) with and without silicosis compared with unexposed reference control group, and their associations with the radiological severity and duration of exposure to silica. METHODS:: Fifty-seven SES; 36 with silicosis and 22 subjects in control group, were included in the study. RESULTS:: CCL3, CCL24, sTNFR1, and sTNFR2 were increased in SES and in SES with silicosis than in controls. There were no differences in the levels of CCL2, CCL11, or tumor necrosis factor alpha. The sTNFR2 level was greater in SES with silicosis than in SES without silicosis. There was a positive correlation between sTNFR1 and sTNFR2 and the radiological severity and time of exposure to silica. sTNFR2 was associated with all categories of radiological severity. CONCLUSION:: sTNFR2 is associated with silicosis severity and early exposure to silica.
AB - OBJECTIVE:: To evaluate the plasma levels of CCL2, CCL3, CCL11, CCL24, tumor necrosis factor alpha, sTNFR1, and sTNFR2 in subjects exposed to silica (SES) with and without silicosis compared with unexposed reference control group, and their associations with the radiological severity and duration of exposure to silica. METHODS:: Fifty-seven SES; 36 with silicosis and 22 subjects in control group, were included in the study. RESULTS:: CCL3, CCL24, sTNFR1, and sTNFR2 were increased in SES and in SES with silicosis than in controls. There were no differences in the levels of CCL2, CCL11, or tumor necrosis factor alpha. The sTNFR2 level was greater in SES with silicosis than in SES without silicosis. There was a positive correlation between sTNFR1 and sTNFR2 and the radiological severity and time of exposure to silica. sTNFR2 was associated with all categories of radiological severity. CONCLUSION:: sTNFR2 is associated with silicosis severity and early exposure to silica.
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U2 - 10.1097/JOM.0000000000000164
DO - 10.1097/JOM.0000000000000164
M3 - Article
C2 - 24806562
AN - SCOPUS:84900810930
SN - 1076-2752
VL - 56
SP - 493
EP - 497
JO - Journal of occupational and environmental medicine
JF - Journal of occupational and environmental medicine
IS - 5
ER -