Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence

Xiaoling Xuei, Leah Flury-Wetherill, Laura Almasy, Laura Bierut, Jay Tischfield, Marc Schuckit, John I. Nurnberger, Tatiana Foroud, Howard J. Edenberg

    Research output: Contribution to journalArticlepeer-review

    37 Scopus citations

    Abstract

    Recent studies in animal models have shown that the nociceptin system, comprising nociceptin (or OFQ/N, encoded by PNOC) and the nociceptin receptor (an opioid receptor-like protein encoded by OPRL1), may be involved in alcohol and other drug reward pathways. To determine whether the nociceptin system is associated with alcohol or illicit drug dependence in humans, we analyzed 10 single nucleotide polymorphisms (SNPs) in OPRL1 and 15 SNPs in PNOC in a sample of 1923 European Americans from 219 multiplex alcohol dependent families ascertained by the Collaborative Study on the Genetics of Alcoholism. The SNPs spanned both genes and several kb of their flanking sequences, and were in high linkage disequilibrium. Neither gene was associated with alcohol or illicit drug dependence, although two SNPs in PNOC showed marginal association with alcoholism and one with illicit drug dependence (P = 0.04-0.05). Secondary analyses suggested that two adjacent SNPs in intron 1 of OPRL1 were marginally associated with opioid dependence (P = 0.05); none of the SNPs in PNOC were associated with opioid dependence.

    Original languageEnglish (US)
    Pages (from-to)80-87
    Number of pages8
    JournalAddiction Biology
    Volume13
    Issue number1
    DOIs
    StatePublished - Mar 2008

    Keywords

    • Alcoholism
    • Association
    • Drug dependence
    • Nociceptin system
    • Opioid
    • Polymorphism

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Pharmacology
    • Psychiatry and Mental health

    Fingerprint Dive into the research topics of 'Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence'. Together they form a unique fingerprint.

    Cite this