Abstract
Objective: This study used the population of the Central Valley of Costa Rica (CVCR) and phenotyping strategies alternative to DSMIV classifications to investigate the association of neuregulin 1 with schizophrenia. Method: Using 134 family trios with a history of psychosis, we genotyped six of the seven markers originally identified to be associated with schizophrenia in Iceland. Results: The neuregulin Icelandic haplotype was not associated with schizophrenia in the CVCR population. However, a novel haplotype was found to be overrepresented in subjects with functional psychosis (global P-value > 0.05). Stratification of the sample by history of mania suggests that this haplotype may be preferentially over-transmitted to persons with a history of manic psychosis. Conclusion: These results suggest that the neuregulin 1 gene is unlikely to play a major role in predisposing to schizophrenia in the CVCR. Further studies in the CVCR and other Latin American populations should be performed in order to corroborate these findings.
Original language | English (US) |
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Pages (from-to) | 314-321 |
Number of pages | 8 |
Journal | Acta Psychiatrica Scandinavica |
Volume | 113 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2006 |
Keywords
- Haplotypes
- Linkage disequilibrium
- Mania
- Psychosis
ASJC Scopus subject areas
- Psychiatry and Mental health