Assignment of xeroderma pigmentosum group c (xpc) gene to chromosome 3p25

Randy J. Legerski, Pu Liu, Lei Li, Carolyn A. Peterson, Ying Zhao, Robin J. Leach, Susan L. Naylor, Michael J. Siciliano

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The human gene XPC (formerly designated XPCC), which corrects the repair deficiency of xeroderma pigmentosum (XP) group C cells, was mapped to 3p25. A cDNA probe for Southern blot hybridization and diagnostic PCR analyses of hybrid clone panels informative for human chromosomes in general and portions of chromosome 3 in particular produced the initial results. Fluorescence in situ hybridization utilizing both a yeast artificial chromosome DNA containing the gene and XPC cDNA as probes provided verification and specific regional assignment. A conflicting assignment of XPC to chromosome 5 is discussed in light of inadequacies in the exclusive use of microcell-mediated chromosome transfer for gene mapping.

Original languageEnglish (US)
Pages (from-to)266-269
Number of pages4
Issue number1
StatePublished - May 1 1994

ASJC Scopus subject areas

  • Genetics


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