Assignment of tyrosine-specific T-cell phosphatase to conserved syntenic groups on human chromosome 18 and mouse chromosome 18

Alan Y. Sakaguchi, Victor L. Sylvia, Lisa Martinez, E. Anne Smith, Eun Soo Han, Peter A. Lalley, Thomas B. Shows, Goutam Ghosh Choudhury

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Phosphorylation of proteins on tyrosine is crucially involved in signal transduction and mitogenesis and is regulated by both kinases and phosphatases. Recently, a number of soluble and transmembrane receptor-linked protein tyrosine phosphatases (PTPase) have been characterized. Among these is a 48.4-kDa PTPase encoded by a cDNA isolated from a T-lymphocyte library by low-stringency screening with probes derived from placental PTPase 1B. A human T-cell PTPase (PTPT) cDNA and somatic cell hybrids were used to assign a PTPT gene to conserved syntentic groups on human chromosome 18 and on mouse chromosome 18. Two unlinked sequences, one on human chromosome 1, were also detected.

Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalGenomics
Volume12
Issue number1
DOIs
StatePublished - Jan 1992

ASJC Scopus subject areas

  • Genetics

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