Assignment of retinoblastoma susceptibility gene to mouse chromosome 14

Chih Lin Hsieh, Wen Hwa Lee, Eva Y.H.P. Lee, Ann M. Killary, Peter A. Lalley, Susan L. Naylor

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A human cDNA probe was used to screen a panel of mouse-Chinese hamster somatic cell hybrids to determine the chromosomal location of the retinoblastoma susceptibility gene (Rb-1)in mouse. The Rb-1 gene mapped to mouse chromosome 14. Thus, the retinoblastoma susceptibility gene is syntenic with esterase 10 (the mouse homolog of human esterase D). The chromosomal assignment of the mouse Rb-1 gene was further confirmed by using the same probe to study mouse-rat microcell hybrids. Since the human retinoblastoma susceptibility gene (RB1)along with the gene for esterase D is on chromosome 13q14, these data indicate this linkage group is conserved in man and mouse.

Original languageEnglish (US)
Pages (from-to)461-464
Number of pages4
JournalSomatic Cell and Molecular Genetics
Volume15
Issue number5
DOIs
StatePublished - Sep 1989

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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