Assessment of serum (1→3)-β-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis

Nathan P. Wiederhold; Laura K. Najvar; Ana C. Vallor; William R. Kirkpatrick; Rosie Bocanegra; Destiny Molina; Marcos Olivo; John R. Graybill; Thomas F. Patterson

doi:10.1128/AAC.01425-07

Assessment of serum (1→3)-β-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis

Nathan P. Wiederhold
, Laura K. Najvar
, Ana C. Vallor
, William R. Kirkpatrick
, Rosie Bocanegra
, Destiny Molina
, Marcos Olivo
, John R. Graybill
, Thomas F. Patterson

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Serum (1→3)-β-D-glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1→3)-ß-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.

Original language	English (US)
Pages (from-to)	1176-1178
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	52
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01425-07
State	Published - Mar 2008

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.01425-07

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Wiederhold, N. P., Najvar, L. K., Vallor, A. C., Kirkpatrick, W. R., Bocanegra, R., Molina, D., Olivo, M., Graybill, J. R., & Patterson, T. F. (2008). Assessment of serum (1→3)-β-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis. Antimicrobial agents and chemotherapy, 52(3), 1176-1178. https://doi.org/10.1128/AAC.01425-07

Wiederhold, NP, Najvar, LK, Vallor, AC, Kirkpatrick, WR, Bocanegra, R, Molina, D, Olivo, M, Graybill, JR & Patterson, TF 2008, 'Assessment of serum (1→3)-β-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis', Antimicrobial agents and chemotherapy, vol. 52, no. 3, pp. 1176-1178. https://doi.org/10.1128/AAC.01425-07

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AU - Kirkpatrick, William R.

AU - Bocanegra, Rosie

AU - Molina, Destiny

AU - Olivo, Marcos

AU - Graybill, John R.

AU - Patterson, Thomas F.

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AB - Serum (1→3)-β-D-glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1→3)-ß-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.

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Assessment of serum (1→3)-β-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis

Abstract

ASJC Scopus subject areas

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