Assessment of serum (1→3)-β-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis

Nathan P. Wiederhold, Laura K. Najvar, Ana C. Vallor, William R. Kirkpatrick, Rosie Bocanegra, Destiny Molina, Marcos Olivo, John R. Graybill, Thomas F. Patterson

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Serum (1→3)-β-D-glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1→3)-ß-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.

Original languageEnglish (US)
Pages (from-to)1176-1178
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume52
Issue number3
DOIs
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Assessment of serum (1→3)-β-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis'. Together they form a unique fingerprint.

Cite this