TY - JOUR
T1 - Assessment of serum (1→3)-β-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosis
AU - Wiederhold, Nathan P.
AU - Najvar, Laura K.
AU - Vallor, Ana C.
AU - Kirkpatrick, William R.
AU - Bocanegra, Rosie
AU - Molina, Destiny
AU - Olivo, Marcos
AU - Graybill, John R.
AU - Patterson, Thomas F.
PY - 2008/3
Y1 - 2008/3
N2 - Serum (1→3)-β-D-glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1→3)-ß-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.
AB - Serum (1→3)-β-D-glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1→3)-ß-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.
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U2 - 10.1128/AAC.01425-07
DO - 10.1128/AAC.01425-07
M3 - Article
C2 - 18160526
AN - SCOPUS:40549143047
VL - 52
SP - 1176
EP - 1178
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 3
ER -