Assessment of Quality of Life following Allogeneic Stem Cell Transplant for Myelofibrosis

Jeanne Palmer, Heidi E. Kosiorek, Christine Wolschke, Veena D.S. Fauble, Richard Butterfield, Holly Geyer, Robyn M. Scherber, Amylou C. Dueck, Allison Gathany, Ruben A. Mesa, Nicolaus Kroger

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Patient-reported outcomes (PROs) for patients with myelofibrosis (MF) have been well characterized, but little is known about quality of life (QoL) following allogeneic stem cell transplantation (allo-SCT). Medical data and PRO measures were collected before transplant and at day 30, day 100, and 1 year after allo-SCT. PRO measures include Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF), Brief Fatigue Inventory, Global Assessment of Change, and Functional Assessment of Cancer Therapy–Bone Marrow Transplant. Forty-four patients who had baseline QoL and at least 1 post-transplant assessment were included. The median age of the patients was 62.5 years (range, 35 to 74 years). At baseline, the mean MPN Total Symptom Score was 28.0, and at day 30, day 100, and 1 year, it was 25.4, 32.3, and 24.3, respectively. However, in myeloproliferative neoplasm-specific symptoms, such as itching, night sweats, bone pain, and fever, a statistically significant improvement was observed for at least 1 time point following transplant. At day 30, 10 (26.3%) patients reported a little/moderately/very much better overall QoL since their transplant, and 26 (68.45%) had a little/moderately/very much worse QoL. At day 100, 10 (30.3%) reported better QoL and 19 (57.6%) reported worsening since transplant. By 1 year, 16 (61.5%) reported feeling better. Our study shows that there is very little change in symptom burden at 1 year following transplant in general, but MF-specific symptoms showed improvement. By 1 year, 61% felt that their QoL was better than it was before transplant.

Original languageEnglish (US)
Pages (from-to)2267-2273
Number of pages7
JournalBiology of Blood and Marrow Transplantation
Volume25
Issue number11
DOIs
StatePublished - Nov 2019

    Fingerprint

Keywords

  • Bone marrow transplant
  • Myelofibrosis
  • Quality of life

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Palmer, J., Kosiorek, H. E., Wolschke, C., Fauble, V. D. S., Butterfield, R., Geyer, H., Scherber, R. M., Dueck, A. C., Gathany, A., Mesa, R. A., & Kroger, N. (2019). Assessment of Quality of Life following Allogeneic Stem Cell Transplant for Myelofibrosis. Biology of Blood and Marrow Transplantation, 25(11), 2267-2273. https://doi.org/10.1016/j.bbmt.2019.07.001