Assessment of liposome delivery using scintigraphic imaging

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11 Scopus citations

Abstract

Scintigraphic imaging is a valuable tool for the development of liposome-based therapeutic agents. It provides the ability to non-invasively track and quantitate the distribution of liposomes in the body. Liposomes labeled with technetium-99 m (99mTc) are particularly advantageous for imaging studies because of their favorable physical characteristics. Examples of how scintigraphic imaging studies have contributed to the evaluation and development of a variety of liposome formulations will be presented. These include liposomes for targeting processes with inflammation associated increased vascular permeability such as healing bone fractures and viral infections; liposomes for intraarticular delivery; and liposomes for delivery of agents to lymph nodes located in the extremities, the mediastinum and the peritoneum. Scintigraphic studies of liposome distribution are very informational and often suggest new drug delivery applications for liposomes.

Original languageEnglish (US)
Pages (from-to)71-80
Number of pages10
JournalJournal of Liposome Research
Volume12
Issue number1-2
DOIs
StatePublished - Aug 15 2002

Keywords

  • Liposomes
  • Lymph node
  • Scintigraphic imaging
  • Technetium-99m (Tc)

ASJC Scopus subject areas

  • Pharmaceutical Science

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