Assessment of coronary arterial restenosis with phase-contrast magnetic resonance imaging measurements of coronary flow reserve

W. Gregory Hundley, L. David Hillis, Craig A. Hamilton, Robert J. Applegate, David M. Herrington, Geoffrey D Clarke, Gregory A. Braden, Mark S. Thomas, Richard A Lange, Ronald M. Peshock, Kerry M. Link

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Background - After successful percutaneous coronary arterial revascularization, 25% to 60% of subjects have restenosis, a recurrent coronary arterial narrowing at the site of the intervention. At present, restenosis is usually detected invasively with contrast coronary angiography. This study was performed to determine if phase-contrast MRI (PC-MRI) could be used to detect restenosis noninvasively in patients with recurrent chest pain after percutaneous revascularization. Methods and Results - Seventeen patients (15 men, 2 women, age 36 to 77 years) with recurrent chest pain >3 months after successful percutaneous intervention underwent PC-MRI measurements of coronary artery flow reserve followed by assessments of stenosis severity with computer-assisted quantitative coronary angiography. The intervention was performed in the left anterior descending coronary artery in 15 patients, one of its diagonal branches in 2 patients, and the right coronary artery in 1 patient. A PC-MRI coronary flow reserve value ≤2.0 was 100% and 82% sensitive and 89% and 100% specific for detecting a luminal diameter narrowing of ≥70% and ≥50%, respectively. Conclusions - Assessments of coronary flow reserve with PC-MRI can be used to identify flow-limiting stenoses (luminal diameter narrowings >70%) in patients with recurrent chest pain in the months after a successful percutaneous intervention.

Original languageEnglish (US)
Pages (from-to)2375-2381
Number of pages7
Issue number20
StatePublished - May 23 2000
Externally publishedYes


  • Coronary disease
  • Magnetic resonance imaging
  • Restenosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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